PMID: 7539036Jun 1, 1995Paper

T cell determinants from autoantibodies to DNA can upregulate autoimmunity in murine systemic lupus erythematosus

The Journal of Experimental Medicine
R R SinghB H Hahn

Abstract

(NZB x NZW) F1 (BWF1) mice develop spontaneous T cell autoimmunity to VH region determinants of syngeneic anti-DNA before the onset of clinical disease. In this study, we characterized the immunogenicity, MHC binding, and lymphokine secretion patterns induced by T cell determinants from the VH region of one such anti-DNA mAb (A6.1) and examined their role in the regulation of autoimmunity. Determinants were identified by proliferation of syngeneic splenic T cells from young, unprimed BWF1 mice in response to overlapping 12-mer peptides representing the entire VH region sequence. Immunization of young BWF1 mice with any of three determinants (A6H 34-45 [p34], A6H 58-69 [p58], and A6H 84-95 [p84]) elicited proliferative responses upon in vitro recall. Upon immunization with the whole A6.1 molecule, however, proliferative responses could be recalled only to the p58 peptide, defining this as immunodominant. The other two peptides (p34 and p84) elicited minimal or no proliferation and could be termed cryptic. Proliferative responses elicited by the cryptic determinants were restricted by a single class II (I-Ed for p34 and I-Au for p84), whereas the immunodominant p58 determinant was restricted by both I-Ed and I-Eu. The cryptic p34...Continue Reading

References

Aug 1, 1992·European Journal of Immunology·V BhardwajE E Sercarz
Jan 11, 1990·Annual Review of Immunology·F D FinkelmanW E Paul
Jun 1, 1990·The Journal of Experimental Medicine·A PuccettiR S Schwartz
Mar 1, 1991·Journal of Immunological Methods·N ChirmuleS Pahwa
Dec 1, 1990·Immunological Reviews·A D SteinbergD M Klinman
Oct 1, 1989·European Journal of Immunology·E K Bikoff, L A Eckhardt
Aug 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·T R MosmannW E Paul
Apr 1, 1987·European Journal of Immunology·W Müller, P Vandenabeele
Feb 1, 1985·The Journal of Experimental Medicine·D Wofsy, W E Seaman
May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·R N GermainJ Y Tou
Jan 1, 1993·Annual Review of Immunology·E E SercarzK Moudgil
Jun 1, 1993·Immunology Today·F Powrie, R L Coffman
Jan 1, 1993·International Reviews of Immunology·B Bogen, S Weiss
Jul 1, 1993·The Journal of Experimental Medicine·R M ChiczJ L Strominger
Feb 1, 1993·Immunology Today·N R NygardB D Schwartz
May 1, 1993·The Journal of Experimental Medicine·C MohanS K Datta

❮ Previous
Next ❯

Citations

Oct 23, 2001·Arthritis and Rheumatism·G RiemekastenF Hiepe
Jan 5, 2005·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Syamal K DattaLuting Xu
Aug 1, 1996·Human Immunology·P LenertJ L Senécal
Jun 1, 2005·Trends in Immunology·Kamal D Moudgil, Eli E Sercarz
Aug 19, 2003·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Ram Raj Singh
Jun 1, 1996·The Journal of Experimental Medicine·A KaliyaperumalS K Datta
Mar 28, 1998·The Journal of Experimental Medicine·D ZengS Strober
Jul 1, 2004·The Journal of Experimental Medicine·Christopher M SnyderLawrence J Wysocki
Sep 16, 2000·Current Opinion in Rheumatology·R R Singh
Oct 31, 1998·Immunological Reviews·J A James, J B Harley
Apr 5, 1997·Annals of the New York Academy of Sciences·S L Peng, J Craft
Apr 5, 1997·Annals of the New York Academy of Sciences·S K Datta, A Kaliyaperumal
Dec 1, 1995·The Journal of Clinical Investigation·R R SinghB H Hahn
Oct 17, 2003·The Journal of Clinical Investigation·Defu ZengSamuel Strober
Nov 5, 2003·The Journal of Clinical Investigation·Brian W BusserTerri M Laufer
Jun 14, 2005·The Journal of Clinical Investigation·Jiankun ZhuChandra Mohan
Nov 20, 1998·The Journal of Clinical Investigation·R R SinghF M Ebling
Sep 30, 1999·Environmental Health Perspectives·T Rao, B Richardson
Apr 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·A WaismanE Mozes
Jun 26, 2001·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M G Robson, M J Walport
Jul 25, 2015·Nephrology·Joanna R GhaliA Richard Kitching
Jan 31, 2012·Cellular Immunology·Emanual Maverakis
Mar 3, 2009·Journal of Autoimmunity·Anne Lise Karlsgot HestvikTrygve Holmøy
Oct 30, 2014·European Journal of Immunology·Lei ShenEdgar G Engleman
Sep 13, 2005·Trends in Immunology·Ram Raj Singh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.