PMID: 8580464Oct 1, 1995Paper

T-cell development and selection in the intestinal epithelium

Seminars in Immunology
P Poussier, M Julius

Abstract

Though it is now well established that T lymphocytes develop in the murine intestinal epithelium, many features of T lymphopoiesis occurring at this site remain controversial and poorly understood. One of the most contentious issues is whether all TcR alpha beta+ iIEL subsets, characterized by the differential expression of CD4, CD8 alpha and CD8 alpha, develop in situ, as suggested by the analysis of athymic radiation chimeras and parabionts. Athymic radiation chimeras have also been used to study positive and negative selection events imposed on developing iIEL expressing an MHC class I restricted transgenic TcR alpha beta. Results reveal that while distinct mechanisms may regulate these processes in the gut, the functional repertoire generated at this site is identical to that resulting from intra-thymic T-cell development. Strikingly, this is not the case for the development and selection of iIEL expressing an MHC class II restricted TcR alpha beta. Features peculiar to MHC class II molecules expressed by enterocytes are discussed in this context. In addition, two model systems are presented towards understanding the basis for the observed oligoclonal repertoire of TcR alpha beta+ iIEL. Specifically, the role of luminal ant...Continue Reading

Citations

Jan 1, 1997·Springer Seminars in Immunopathology·L LefrançoisL Puddington
Aug 5, 1998·Proceedings of the National Academy of Sciences of the United States of America·S T PageA M Pullen
May 26, 1998·Journal of Neuroimmunology·B EngelhardtS A Michie
Nov 6, 1998·The Journal of Experimental Medicine·L HaughnM Julius

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.