PMID: 9529325May 16, 1998Paper

T cell development in mice lacking all T cell receptor zeta family members (Zeta, eta, and FcepsilonRIgamma)

The Journal of Experimental Medicine
E W ShoresP E Love

Abstract

The zeta family includes zeta, eta, and FcepsilonRIgamma (Fcgamma). Dimers of the zeta family proteins function as signal transducing subunits of the T cell antigen receptor (TCR), the pre-TCR, and a subset of Fc receptors. In mice lacking zeta/eta chains, T cell development is impaired, yet low numbers of CD4+ and CD8+ T cells develop. This finding suggests either that pre-TCR and TCR complexes lacking a zeta family dimer can promote T cell maturation, or that in the absence of zeta/eta, Fcgamma serves as a subunit in TCR complexes. To elucidate the role of zeta family dimers in T cell development, we generated mice lacking expression of all of these proteins and compared their phenotype to mice lacking only zeta/eta or Fcgamma. The data reveal that surface complexes that are expressed in the absence of zeta family dimers are capable of transducing signals required for alpha/beta-T cell development. Strikingly, T cells generated in both zeta/eta-/- and zeta/eta-/--Fcgamma-/- mice exhibit a memory phenotype and elaborate interferon gamma. Finally, examination of different T cell populations reveals that zeta/eta and Fcgamma have distinct expression patterns that correlate with their thymus dependency. A possible function for th...Continue Reading

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Citations

Jun 12, 2003·Developmental and Comparative Immunology·Sergei V GuselnikovAlexander V Taranin
Apr 22, 1999·Immunology Today·G C Tsokos, S N Liossis
Jul 14, 2000·Immunity·P E Love, E W Shores
Mar 22, 2002·Nature Reviews. Immunology·T W MakP S Ohashi
Apr 9, 2008·Immunology and Cell Biology·Fang HuangHua Gu
Nov 20, 2002·The Journal of Experimental Medicine·Sandra M HayesPaul E Love
Mar 17, 2004·The Journal of Experimental Medicine·Amy ReichlinMichel C Nussenzweig
Feb 25, 2005·The Journal of Experimental Medicine·Pilar Delgado, Balbino Alarcón
Jan 19, 2006·The Journal of Experimental Medicine·Sandra M Hayes, Paul E Love
Sep 5, 2012·The Journal of Experimental Medicine·Sujin HwangPaul E Love
Jun 8, 1999·Annual Review of Immunology·E SebzdaP S Ohashi
Nov 18, 2005·Blood·Sabrina ChiesaElena Tomasello
Dec 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·J B DeJarnetteP E Love
Feb 13, 2007·Immunological Reviews·Sandra M Hayes, Paul E Love
Apr 15, 2005·Molecular Immunology·Jonathan D SilkJulian Dyson
Dec 24, 1998·Lupus·M Zouali
Feb 12, 2002·Nature Immunology·Francesco ColucciJames P Di Santo
Apr 26, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Takashi MatsuoTsuneyo Mimori
Nov 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Charles D KaplanAlison Finnegan
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·M C HaksA M Kruisbeek
Aug 28, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Guo-Min DengGeorge C Tsokos
Dec 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·N M HaynesP K Darcy
Jun 19, 2004·International Reviews of Immunology·Tsutomu TakeuchiTohru Abe

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