PMID: 31379886DOI: 10.3389/fimmu.2019.01719Aug 6, 2019Paper
T Cell Dysfunction in Cancer Immunity and Immunotherapy
Frontiers in Immunology
Anliang XiaXiao-Jie Lu
Abstract
In cancer, T cells become dysfunctional owing to persistent antigen exposure. Dysfunctional T cells are characterized by reduced proliferative capacity, decreased effector function, and overexpression of multiple inhibitory receptors. Due to the presence of various inhibitory signals in the complex tumor microenvironment, tumor-specific T cells have distinct dysfunction states. Therapeutic reactivation of tumor-specific T cells has yielded good results in cancer patients. Here, we review the hallmarks of T cell dysfunction in cancer. Also, we discuss the relationship between T cell dysfunction and cancer immunotherapy.
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