T Cell Dysfunction in Cancer Immunity and Immunotherapy

Frontiers in Immunology
Anliang XiaXiao-Jie Lu

Abstract

In cancer, T cells become dysfunctional owing to persistent antigen exposure. Dysfunctional T cells are characterized by reduced proliferative capacity, decreased effector function, and overexpression of multiple inhibitory receptors. Due to the presence of various inhibitory signals in the complex tumor microenvironment, tumor-specific T cells have distinct dysfunction states. Therapeutic reactivation of tumor-specific T cells has yielded good results in cancer patients. Here, we review the hallmarks of T cell dysfunction in cancer. Also, we discuss the relationship between T cell dysfunction and cancer immunotherapy.

References

Feb 1, 1995·The Journal of Experimental Medicine·L PialiR H Gisler
Aug 1, 1995·The Journal of Experimental Medicine·M F Krummel, J P Allison
Dec 22, 1998·The Journal of Experimental Medicine·A J ZajacR Ahmed
Feb 5, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·A D WeinbergJ Shields
Mar 13, 2001·Annual Review of Immunology·K W MooreA O'Garra
Jul 18, 2002·Immunity·Kenneth A FrauwirthCraig B Thompson
Aug 13, 2003·The Journal of Experimental Medicine·Cristina BottinoAlessandro Moretta
Mar 23, 2004·Annual Review of Immunology·Sidney PestkaPaul B Fisher
Sep 24, 2004·The Journal of Experimental Medicine·Mary Jo TurkAlan N Houghton
Oct 7, 2004·The Journal of Nutrition·D Scott Lind
Nov 8, 2005·Nature Immunology·Andrew M IntlekoferSteven L Reiner
Nov 16, 2005·Nature Immunology·Chen ZhuVijay K Kuchroo
Jan 27, 2007·Blood·Karin FischerMarina Kreutz
Feb 17, 2007·Nature Immunology·Arlene H SharpeGordon J Freeman
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Paola AgnelliniAnnette Oxenius
May 4, 2007·The Journal of Clinical Investigation·David H Munn, Andrew L Mellor
Nov 23, 2007·Nature·Lauren W CollisonDario A A Vignali
Sep 20, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kenneth J OestreichJeremy M Boss
Feb 7, 2009·Nature Reviews. Immunology·Dmitry I Gabrilovich, Srinivas Nagaraj
Apr 22, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Julien FourcadeHassane M Zarour
May 21, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christine M BucksPeter D Katsikis
Jul 29, 2009·European Journal of Immunology·Markus MunderPascale Kropf
Feb 18, 2010·Proceedings of the National Academy of Sciences of the United States of America·Michael A CurranJames P Allison
Mar 24, 2010·Annual Review of Immunology·Michael Croft
Apr 7, 2010·Current Opinion in Immunology·Julie M Curtsinger, Matthew F Mescher
Apr 14, 2010·Proceedings of the National Academy of Sciences of the United States of America·Junko MatsuzakiKunle Odunsi
Jun 8, 2010·The New England Journal of Medicine·F Stephen HodiWalter J Urba
Jun 12, 2010·Immunological Reviews·Gordon J FreemanRosemarie H DeKruyff
Jun 18, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Erikka L CarrKenneth A Frauwirth
Jul 20, 2010·Immunological Reviews·Weiguo Cui, Susan M Kaech
Jul 20, 2010·Immunological Reviews·Loise M FranciscoArlene H Sharpe

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Citations

Nov 7, 2019·Cells·Muhammad HaseebSangdun Choi
Apr 1, 2020·International Journal of Molecular Sciences·Stefania RaimondoSimona Fontana
May 3, 2020·IUBMB Life·Beata JagielskaElzbieta Sarnowska
Aug 1, 2020·Integrative Cancer Therapies·Ming SunWenyan Zhao
May 7, 2020·Journal of Leukocyte Biology·Olga LeplinaElena Chernykh
Mar 3, 2020·Frontiers in Cell and Developmental Biology·Zhen ZhangYi Zhang
Mar 12, 2020·Immune Network·Hye Won LeeTae Jin Kim
May 26, 2020·Journal for Immunotherapy of Cancer·Dora Lucia Vallejo ArdilaMarcos Vinicius Perini
May 13, 2020·Cancer Immunology, Immunotherapy : CII·Reem SalehEyad Elkord
May 8, 2020·International Journal of Molecular Sciences·Ji Hye KimHwan-Suck Chung
Aug 28, 2020·Frontiers in Immunology·Zachary JacksonJane S Reese
Sep 29, 2020·Frontiers in Immunology·Kevin X Liu, Shweta Joshi
Jul 19, 2020·International Journal of Molecular Sciences·Cody BarbariRahul R Deshmukh
May 8, 2020·Nuclear Medicine and Molecular Imaging·Niklaus SchaeferMargret Schottelius
Jun 26, 2020·International Journal of Molecular Sciences·Omid KooshkakiBehzad Baradaran
Sep 4, 2020·Diagnostics·Anca OnaciuIoana Berindan-Neagoe
Jul 24, 2020·Cellular & Molecular Immunology·Xingyi Pan, Lei Zheng
May 28, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Paolo CravediPeter S Heeger
Jan 13, 2021·The Journal of Experimental Medicine·Masahiro KiuchiToshinori Nakayama
Nov 20, 2020·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Mihaela AldeaJean-Marie Michot
Oct 31, 2020·Frontiers in Immunology·Julia BusselaarJannie Borst
Jan 26, 2021·Breast Cancer : Targets and Therapy·Eduardo FleuryGabriel Salum D'Alessandro
Feb 13, 2021·Cancers·Pinelopi A NikolopoulouVassiliki Kostourou
Nov 13, 2020·Frontiers in Cell and Developmental Biology·Kaijian ZhouGuoxin Liang
Feb 12, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jaehyun KimYong-Hee Kim
Nov 22, 2020·Methods and Protocols·Mateusz Kotowski, Sumana Sharma
Feb 20, 2021·Cytokine: X·Julian J Freen-van Heeren
Mar 2, 2021·Frontiers in Oncology·Xiuzhen ZhangPing Wang
Feb 19, 2021·The Journal of Experimental Medicine·Puneeth GuruprasadMarco Ruella
Oct 16, 2020·Expert Opinion on Drug Discovery·Mei Ding, David Baker
Mar 21, 2021·Journal of Hematology & Oncology·Julian A Marin-AcevedoYanyan Lou
Apr 4, 2021·Cells·Hengbo ZhouTimothy P Padera
Apr 10, 2021·Frontiers in Immunology·Preethi Bala Balakrishnan, Elizabeth E Sweeney

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Methods Mentioned

BETA
xenograft

Clinical Trials Mentioned

NCT03298828

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