PMID: 6980586Aug 1, 1982Paper

T-cell dysfunction in minimal-change nephrotic syndrome of childhood

American Journal of Diseases of Children
P FodorL Schlesinger

Abstract

Cell-mediated immunity was studied in 25 children with minimal-change nephrotic syndrome in different stages of their disease. This was assessed by delayed cutaneous hypersensitivity reactions, number of T lymphocytes, and blastogenic response to phytohemagglutinin and PPD. Patients with active nephrosis could not become sensitized to dinitrochlorobenzene and had decreased response to common recall antigens. T-cell number ranged within normal values in all nephrotic patients. During active disease, lymphocyte transformation was markedly reduced, but improved considerably when cells were cultured in normal plasma. During remission, patients showed normal proliferative response. Reactivity of normal lymphocytes to both stimulants was inhibited by nephrotic plasma. Our results suggest the existence of a serum factor that affects T-cell function.

Citations

Sep 21, 2013·Indian Journal of Nephrology·N GeorgeG Basu
Jul 1, 1985·The Journal of Clinical Investigation·H W Schnaper, T M Aune
Feb 1, 1986·Archives of Disease in Childhood·K P MehtaU Kolhatkar
May 1, 1990·Irish Journal of Medical Science·W MedawarJ J Walshe
Jul 1, 1989·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·C Y LinP P Lee
Apr 1, 1994·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·S A HultonM J Dillon
Jan 1, 1989·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·H W Schnaper
Jun 1, 1988·Kidney International·D B Bernard
Sep 1, 1991·Kidney International·A KoyamaM Narita
Mar 20, 2012·Néphrologie & thérapeutique·Dil SahaliPhilippe Lang
Oct 15, 2013·Journal of Paediatrics and Child Health·Sharon TeoAndrew Steer
Mar 1, 2005·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·P FrangeG Deschênes
Jun 1, 1989·Journal of Autoimmunity·M Broyer, P Niaudet
Dec 1, 1987·The Journal of Pediatrics·A TejaniM R Khawar
May 1, 1991·Archives of Disease in Childhood·U B Berg
Aug 29, 2019·Frontiers in Pediatrics·Shamitha Thishakya GoonewardenePriyia Pusparajah
Dec 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Asta ValanciutéDjillali Sahali
Oct 28, 2008·Médecine sciences : M/S·Vincent AudardDil Sahali
Jan 31, 2019·Frontiers in Physiology·Sanjana GuptaStephen B Walsh
Apr 19, 2002·Journal of the American Society of Nephrology : JASN·Robyn Cunard, Carolyn J Kelly
Jul 20, 2001·Journal of the American Society of Nephrology : JASN·Djillali SahaliGeorges Guellaen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.