T Cell Epitope Peptide Therapy for Allergic Diseases

Current Allergy and Asthma Reports
Robyn E O'HehirJennifer M Rolland

Abstract

Careful selection of dominant T cell epitope peptides of major allergens that display degeneracy for binding to a wide array of MHC class II molecules allows induction of clinical and immunological tolerance to allergen in a refined treatment strategy. From the original concept of peptide-induced T cell anergy arising from in vitro studies, proof-of-concept murine models and flourishing human trials followed. Current randomized, double-blind, placebo-controlled clinical trials of mixtures of T cell-reactive short allergen peptides or long contiguous overlapping peptides are encouraging with intradermal administration into non-inflamed skin a preferred delivery. Definitive immunological mechanisms are yet to be resolved but specific anergy, Th2 cell deletion, immune deviation, and Treg induction seem implicated. Significant efficacy, particularly with short treatment courses, in a range of aeroallergen therapies (cat, house dust mite, grass pollen) with inconsequential non-systemic adverse events likely heralds a new class of therapeutic for allergy, Synthetic Peptide Immuno-Regulatory Epitopes (SPIRE).

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Citations

Feb 24, 2016·Expert Review of Clinical Pharmacology·Cristoforo IncorvaiaErminia Ridolo
Aug 17, 2016·Biotechnology Journal·Momoko KitaokaMasahiro Goto
Jan 20, 2017·Critical Reviews in Food Science and Nutrition·Daniel Lozano-Ojalvo, Rosina López-Fandiño
Feb 17, 2018·Current Allergy and Asthma Reports·Pattraporn SatitsuksanoaMübeccel Akdis
May 17, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jie LiRongfei Zhu
Jun 18, 2019·Molecular Nutrition & Food Research·Stephanie EichhornGabriele Gadermaier
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May 11, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Oliver PfaarStefan Schülke
Sep 25, 2021·Immunotherapy·Rashi RamchandaniAnne K Ellis

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Methods Mentioned

BETA
flow cytometry
transgenic
biopsies

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