T-cell exhaustion in HIV infection.

Current HIV/AIDS Reports
Mohamed El-FarElias K Haddad

Abstract

Generation of memory T cells, which mediate immunity against microbes and cancers, relies, for optimal activity, on the interactions of multiple cell types that are highly regulated through the expression of soluble factors and negative and positive receptors. Their disruption will lead to aberrant immune responses, which can result in the invasion of the host by foreign pathogens. In chronic viral infections including HIV and hepatitis C virus, persistence of antigen and lack of CD4 help (HIV) disrupt memory T-cell function and induce defects in memory T-cell responses, which have been defined as T-cell exhaustion. In this review, we examine the molecular mechanisms involved in such T-cell dysfunction. Better understanding of these mechanisms will assist in the development of novel therapies to prevent the immune damage mediated by HIV infection.

References

Mar 1, 1991·Immunology Today·T R Mosmann, K W Moore
Oct 1, 1994·Research in Immunology·D J BlackbournJ A Levy
Mar 11, 1998·Proceedings. Biological Sciences·D WodarzM A Nowak
May 23, 1998·Annual Review of Immunology·R W DuttonS L Swain
Dec 18, 1998·Science·K M LeeJ A Bluestone
Dec 22, 1998·The Journal of Experimental Medicine·A J ZajacR Ahmed
May 4, 2000·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·S L Swain
Mar 10, 2001·Nature·P ChampagneG Pantaleo
Feb 28, 2002·Annual Review of Immunology·Beatriz M Carreno, Mary Collins
Apr 3, 2002·Nature Medicine·Victor AppaySarah L Rowland-Jones
Apr 26, 2002·Current Opinion in Immunology·Rebecca J GreenwaldArlene H Sharpe
May 3, 2002·Nature·Daniel C DouekRichard A Koup
Aug 31, 2002·Cellular Immunology·Jacqueline M McBrideGregorio Aversa
Jan 8, 2003·Reviews in Medical Virology·Katherine KedzierskaAnthony L Cunningham
Jul 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jens M ChemnitzJames L Riley
Jun 11, 2005·Immunology·Yolanda D MahnkeVolker Schirrmacher
Nov 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nilufer SethKai W Wucherpfennig
Aug 19, 2006·Nature Medicine·Lydie TrautmannRafick-Pierre Sekaly
Aug 26, 2006·Science·Helga SchneiderChristopher E Rudd
Sep 7, 2006·The Journal of Experimental Medicine·Constantinos PetrovasRichard A Koup
Oct 17, 2006·Nature Medicine·David G BrooksMichael B A Oldstone
Jan 5, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Souheil-Antoine YounesRafick-Pierre Sekaly

❮ Previous
Next ❯

Citations

Dec 29, 2010·Current HIV/AIDS Reports·Alka Khaitan, Derya Unutmaz
Aug 23, 2011·AIDS Research and Human Retroviruses·Susan F PlaegerAlan Embry
Oct 3, 2012·AIDS Research and Human Retroviruses·Kaitlin Rainwater-LovettWilliam J Moss
Jan 10, 2013·AIDS Research and Human Retroviruses·Ivan LandiresJacques Thèze
Dec 3, 2011·Current Opinion in HIV and AIDS·Yoav PeretzRafick-Pierre Sékaly
May 5, 2010·The Journal of Clinical Investigation·Galit AlterMarcus Altfeld
Apr 24, 2012·The Journal of Clinical Investigation·Jacob D Estes
Jun 30, 2012·Critical Care : the Official Journal of the Critical Care Forum·Jonathan S BoomerJonathan M Green
Mar 15, 2014·PLoS Pathogens·Nathan L BowersZdenek Hel
Sep 3, 2014·Journal of Translational Medicine·Mohamed El-FarGeorge Kukolj
Apr 4, 2013·Seminars in Immunology·Deanna A KulpaRafick-Pierre Sékaly
Apr 7, 2012·Journal of Theoretical Biology·Sarah M Roy, Dominik Wodarz
Mar 16, 2016·Scientific Reports·Mohamed El-FarUNKNOWN Investigators of the Canadian HIV+ Slow Progressor Cohort
May 10, 2016·JCI Insight·Eileen P ScullyMarcus Altfeld
Apr 18, 2015·The Journal of Infectious Diseases·Carolina PomboMichael R Betts
Mar 11, 2015·Retrovirology·Vijayakumar VeluEsaki M Shankar
Jan 27, 2015·Virology·Shannon M KahanAllan J Zajac
Jun 27, 2014·Vaccine·Authors Kevin FisherRichard Jefferys
Dec 24, 2014·American Journal of Respiratory and Critical Care Medicine·C Preston NeffAndrew P Fontenot
Jul 11, 2014·Current Opinion in HIV and AIDS·Vijay K KuchrooConstantinos Petrovas
Dec 12, 2018·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Gordana HalecShehnaz K Hussain
Jan 25, 2019·Annual Review of Immunology·Laura M McLaneE John Wherry
Nov 13, 2019·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Sarah M ZaidanUNKNOWN Canadian HIV and Aging Cohort Study
Aug 20, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kathryn J MackernessAllan J Zajac
Dec 3, 2015·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Carey L ShiveMichael M Lederman
Apr 4, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael J MolloyEdward J Usherwood
Oct 16, 2018·Frontiers in Immunology·Gu-Lung LinAndrew J Pollard
Nov 8, 2017·Archives of Dermatological Research·Soheil Tavakolpour
Aug 24, 2019·Frontiers in Immunology·Chansavath PhetsouphanhJohn Frater
Aug 30, 2020·International Journal of Molecular Sciences·Huy NguyenVishwanath Venketaraman
Jul 27, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Afework KassuBrent E Palmer

❮ Previous
Next ❯

Related Concepts

Related Feeds

HIV/AIDS-Related Malignancies

HIV/AIDS infection increases the risk of non-communicable diseases common in the aged including HIV/AIDS-related malignancies. Discover the latest research in HIV/AIDS-related malignancies.