T cell expression of CIITA represses Th1 immunity

International Immunology
Weon Seo ParkKyeong Cheon Jung

Abstract

Despite the fact that major histocompatibility complex class II transactivator (CIITA) has been known to be involved in Th1/Th2 balance in addition to its major role as a master regulator for the expression of MHC class II genes, the exact role of CIITA in Th1/Th2 balance is still controversial. To investigate whether the Th1/Th2 balance could be modulated by T cell specific expression of CIITA, we generated CIITA-transgenic mice, in which the CIITA expression is controlled by the distal promoter of p56lck, resulting in constitutive expression of CIITA predominantly in peripheral T cells. Naive CD4+ T cells from CIITA-transgenic mice exhibited a low level of IFN-gamma secretion as well as impaired Th1 polarization in vitro, while IL-4 secretion was enhanced under Th2 condition. In addition, the development of experimental autoimmune encephalomyelitis (EAE), a prototype of Th1-mediated disease, was repressed in CIITA-transgenic mice. Resistance to EAE was correlated with reduced production of IFN-gamma in response to MOG35-55, while the proliferation of MOG35-55 -specific T cells was not affected in CIITA-transgenic mice. Together, these data demonstrate that overexpression of CIITA in T cells inhibits Th1 differentiation and fu...Continue Reading

Citations

Nov 26, 2008·Immunology and Cell Biology·You Jeong LeeSeong Hoe Park
Mar 2, 2011·Immunology and Cell Biology·Eun Ji KimKyeong Cheon Jung
Oct 4, 2005·Nature Reviews. Immunology·Walter ReithJean-Marc Waldburger
Aug 29, 2007·The Journal of Experimental Medicine·Wei LiCheong-Hee Chang
Aug 15, 2006·Immunological Reviews·Jens LohrAbul K Abbas
Mar 5, 2011·British Journal of Pharmacology·Cris S ConstantinescuBruno Gran
Jan 19, 2010·Molecular Immunology·M Hanief SofiCheong-Hee Chang
May 17, 2006·European Journal of Immunology·Luc A OttenWalter Reith
Oct 18, 2006·Journal of Korean Medical Science·Tae Woon KimKyeong Cheon Jung
Feb 2, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·M Hanief SofiCheong-Hee Chang

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