PMID: 8611452Apr 1, 1996Paper

T-cell form of chronic lymphocytic leukaemia: a reaffirmation of its existence

British Journal of Haematology
K F WongV C Sin

Abstract

Early in the 1980s three categories of T-cell chronic lymphocytic leukaemia were recognized: CD4+ CD8- knobby type, CD4- CD8+ azurophilic type and CD4+ CD8- adult T-cell leukaemia (ATL) type. Both azurophilic and ATL types were later shown to be distinctive disorders, whereas the knobby type has been largely neglected and even considered non-existent by some authors. In this report we describe two patients with leukaemia of CD3+ CD4+ CD8- post-thymic T lymphocytes presenting with marked lymphocytosis, generalized lymphadenopathy and hepatosplenomegaly. We believe that CLL of the post-thymic T-lymphocytes is a distinct entity, and merits a separate designation from other T-cell leukaemias.

Citations

May 5, 2005·Current Treatment Options in Oncology·Ahmed AbsiMatt Kalaycio
Apr 25, 2012·International Journal of Hematology·Junichi KameokaKenichi Sawada
Apr 6, 2004·Leukemia & Lymphoma·Keiko AndoKazuma Ohyashiki
Dec 11, 2003·The Veterinary Clinics of North America. Small Animal Practice·Heather C Workman, William Vernau
Sep 26, 2003·American Journal of Hematology·Francesco CavazziniGianluigi Castoldi

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