PMID: 6454746May 1, 1981Paper

T cell growth factor abrogates concanavalin A-induced suppressor cell function

The Journal of Experimental Medicine
R Palacios, G Möller

Abstract

Concanavalin A (Con-A)-induced suppressor T cells were found to respond to T cell growth factor (TCGF) by proliferation. TCGF abrogated the suppressor activity exerted by these cells on phytohemagglutinin (PHA)- and alloantigen- induced lymphocyte proliferation and on pokeweed mitogen (PWM)-driven immunoglobulin secretion. The Con-A-activated suppressor T cells absorbed the TCGF activity, preincubation of these active suppressor cells with TCGF abolished their suppressor activity and addition of increasing numbers of Con-A-activated T cells reverted the abrogator,/ effect of TCGF. Altogether, these findings suggest that Con-A-induced suppressor T cells exert their function by decreasing the available levels of TCGF. Cyclosporin-A (CYA), which is known to inhibit the expression of receptors for TCGF on T cells, also inhibited the suppressor activity as determined in both indicator systems, namely PHA- or alloantigen-induced DNA synthesis and PWM-induced immunoglobulin synthesis. CYA made Con-A-treated T cells unresponsive to TCGF and unable to absorb the growth factor, supporting the notion that CYA inhibits the expression of TCGF receptors on T cells, a mechanism by which this drug seems to abrogate Con-A-induced suppressor T c...Continue Reading

References

May 1, 1976·The Journal of Experimental Medicine·L ShouR A Good
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Aug 1, 1976·European Journal of Immunology·E GronowiczF Melchers
Jun 1, 1980·The Journal of Clinical Investigation·R PalaciosE Díaz-Jouanen

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Citations

Jan 1, 1986·Springer Seminars in Immunopathology·R H ZublerP A Miescher
Sep 1, 1987·Clinical Rheumatology·S SierakowskiJ S Goodwin
May 1, 1994·Diabetologia·T TomodaT Taniguchi
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Sep 1, 1982·The Journal of Experimental Medicine·M S SyR Finberg
Dec 1, 1983·The Journal of Experimental Medicine·M Beckwith, S Rich
Jan 1, 1990·Scandinavian Journal of Immunology·L PelletierP Druet
Jun 1, 1982·The Journal of Clinical Investigation·J Alcocer-Varela, D Alarcón-Segovia
Aug 1, 1986·The Journal of Clinical Investigation·M B BaniaB G Arnason
Jan 1, 1982·Immunological Reviews·T R Cupps, A S Fauci
Sep 1, 1981·Scandinavian Journal of Immunology·R Palacios
Oct 1, 1982·Scandinavian Journal of Immunology·C WoodG Möller
Mar 1, 1988·Scandinavian Journal of Immunology·G Möller
Jan 1, 1986·Annals of the New York Academy of Sciences·P J LammieA G Bentley
Jan 1, 1986·Scandinavian Journal of Immunology·B Davidsen, E Kristensen
Jan 1, 1989·American Journal of Reproductive Immunology : AJRI·P A GatenbyS Adelstein

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