T cell help to B cells in germinal centers: putting the jigsaw together

International Reviews of Immunology
Uthaman GowthamanJaved N Agrewala

Abstract

The germinal center (GC) reaction supports the processes of affinity maturation and class switching in B cells that result in long-lasting humoral immunity. CD4(+) T follicular helper cells (Tfh) participate in the GC reaction to help B cells. However, recent studies highlight the heterogeneity of CD4(+) T cells in GCs, which confounds the understanding of Tfh cells. Based on many recent studies, we have tried to form a working model on the niche of Tfh cells in GCs. We have also addressed whether Tfh cells are a distinct lineage and how they may be generated to help B cells.

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Aug 26, 2014·Immunology Letters·Colleen J Winstead
Aug 8, 2015·Periodontology 2000·José R Gonzales
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Jan 9, 2015·PLoS Neglected Tropical Diseases·Mohammad IslamuddinFarhat Afrin

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