T cell immune responses to haptens. Structural models for allergic and autoimmune reactions

Toxicology
H U WeltzienJ Kohler

Abstract

Protein-reactive chemicals, metal salts and drugs, commonly classified as immunological haptens, are major environmental noxes targeted at the immune system of vertebrates. They may not only interfere with this defense system by toxicity alone, but more often by evoking hapten-specific immune responses resulting in allergic and eventually autoimmune responses. Here, we review recent developments in the analysis of the structural basis of hapten recognition, particularly by T lymphocytes, which represent central elements in cell-mediated, as well as in IgE dependent, allergies. A break-through in this field was the finding that T cells detect haptens as structural entities, attached covalently or by complexation to self-peptides anchored in binding grooves of major histocompatibility antigens (MHC-proteins). Synthetic hapten-peptide conjugates were shown to induce hapten-specific contact sensitivity in mice, opening new routes for studying hapten-induced immune disorders.

References

Feb 1, 1978·The Journal of Experimental Medicine·A M Schmitt-VerhulstG M Shearer
Sep 1, 1979·European Journal of Immunology·H PohlitH von Boehmer
Jan 1, 1992·The Journal of Clinical Investigation·P RomagnoliF Sinigaglia
Sep 26, 1991·Nature·T S JardetzkyD C Wiley
Apr 1, 1989·Allergy·S J Bell, W J Pichler
Apr 1, 1989·Current Opinion in Immunology·A L de Weck
Oct 1, 1986·The Journal of Allergy and Clinical Immunology·M KoponenA L de Weck
Aug 1, 1974·European Journal of Immunology·G M Shearer
May 1, 1994·International Archives of Allergy and Immunology·S Martin, H U Weltzien
Mar 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·D H FremontI A Wilson
Jan 1, 1995·Immunogenetics·H G RammenseeS Stevanoviíc
Jul 1, 1994·The Journal of Investigative Dermatology·J MaM Bigby
May 1, 1994·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M BlancaJ Fernandez
Apr 1, 1994·The Journal of Investigative Dermatology·F Sinigaglia
Jan 28, 1994·Cell·H von Boehmer
Feb 1, 1993·Current Opinion in Immunology·M M Davis, Y Chien

❮ Previous
Next ❯

Citations

May 16, 1998·European Journal of Immunology·R AlbersR Pieters
Mar 16, 2002·Current Allergy and Asthma Reports·Werner J Pichler
Aug 15, 2002·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·H KatoH Kaneko
Aug 24, 1999·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·I KimberD A Basketter
Mar 22, 2001·Toxicology in Vitro : an International Journal Published in Association with BIBRA·C A RyanG F Gerberick
May 30, 2003·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Ian Kimber, Rebecca J Dearman
Apr 9, 2002·Australian Family Physician·Mary Christoforou
Sep 25, 2002·Allergy·W PichlerA Helbling
Mar 31, 2007·Nature Clinical Practice. Rheumatology·Meghavi KosbothWestley H Reeves
Dec 21, 2000·Immunology·J Zhang-HooverJ Stein-Streilein
Aug 14, 2010·Avian Pathology : Journal of the W.V.P.A·Gonzalo J DiazHerman J Boermans
May 23, 1998·Allergy·W J PichlerS von Greyerz
Sep 19, 2000·Thorax·W J Pichler, N Yawalkar
Apr 6, 2006·The AAPS Journal·Joseph P SandersonB Kevin Park
Sep 30, 1999·Environmental Health Perspectives·R Pieters, R Albers
Sep 30, 1999·Environmental Health Perspectives·C C MichielsenJ G Vos
May 16, 2002·American Journal of Clinical Dermatology·Werner J PichlerDean Naisbitt
Jun 21, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jon F LalkoRebecca J Dearman
Feb 16, 2006·Current Allergy and Asthma Reports·Andrea Cavani, Ornella De Pità
Sep 23, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Sander DikEmiel Rorije
Sep 21, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K CederbrantP Hultman
Jan 1, 1996·European Journal of Immunology·E PadovanH U Weltzien
Sep 17, 2010·Therapeutic Drug Monitoring·Alfredo Tartarone, Rosa Lerose
Mar 2, 2010·Expert Review of Neurotherapeutics·Klaus Lauer
Mar 21, 2007·Expert Opinion on Drug Safety·Dean J NaisbittB Kevin Park
Feb 18, 2010·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Philippe Paquet, Gérald E Piérard
Oct 21, 2009·Allergy·M VocansonJ-F Nicolas
Oct 14, 2010·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Guilherme G dos SantosSusan Gibbs
Nov 3, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Krista OuwehandSusan Gibbs
Sep 30, 2006·The Journal of Investigative Dermatology·Chris PickardPeter S Friedmann
Aug 19, 2007·The Journal of Allergy and Clinical Immunology·Chih-Wen Ou YangYuan-Tsong Chen
Aug 2, 2007·Hematology/oncology Clinics of North America·Gian Paolo Visentin, Chao Yan Liu
Dec 13, 2006·Methods : a Companion to Methods in Enzymology·Raymond Pieters
Jul 24, 2004·The British Journal of Dermatology·H MoedT Rustemeyer
Aug 13, 2005·Proteomics·Kirsten HeissHermann-Josef Thierse
Jan 8, 2009·Contact Dermatitis·Mascha J ToebakThomas Rustemeyer
Oct 11, 2008·Contact Dermatitis·Claudia SkazikBrunhilde Blömeke

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.