T cell immunity induced by a bivalent Salmonella-based CEACAM6 and 4-1BBL vaccines in a rat colorectal cancer model

Oncology Letters
Chunhui JinJian-Xin Ye

Abstract

The present study investigated the anti-tumor mechanisms of recombinant non-specific cross-reacting antigen (CEACAM6) and 4-1BB ligand (4-1BBL) Salmonella-based vaccines, and the effect that these vaccinations have on memory T cells and T helper (Th) cell polarization. Colon tumors were induced in rats via 1,2-dimethylhydrazine (DMH) injections. Rats were then treated with injections of attenuated Salmonella typhimurium carrying pIRES-CEACAM6, pIRES-4-1BBL or pIRES-CEACAM6-4-1BBL. In total, 4 vaccine injections, one every other week, were administered during the 8 weeks subsequent to the DMH injection. Rats were sacrificed 18 weeks subsequent to the DMH injections, and the colons and spleens were collected for further analysis. Cluster of differentiation (CD) 45RO, interleukin (IL)-4 and IL-17 expression was analyzed in colon tumor tissues, and the expression of interferon (IFN)-γ, CD3+, CD4+, CD8+, CD56+, forkhead/winged-helix transcription factor box P3 (FOXP3+), IL-4 and IL-17 were analyzed in splenic tissues. Compared with the pIRES/SL3261 group, the pIRES-CEACAM6-4-1BBL/SL3261 treatment group had a significantly higher number of CD45RO+ expressing tumor infiltrating lymphocytes and lower expression levels of IL-4 and IL-17...Continue Reading

References

Oct 31, 1996·Nature·A K AbbasA Sher
Jan 11, 2003·Science·Shohei HoriShimon Sakaguchi
Sep 27, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Peter JantscheffChristoph Rochlitz
Dec 13, 2003·Cancer Gene Therapy·Adam T C CheukBarbara-ann Guinn
Jul 22, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hideki KawaiJunichi Ogawa
Oct 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Muneo NumasakiHidetada Sasaki
Dec 24, 2005·The New England Journal of Medicine·Franck PagèsJérôme Galon
Sep 27, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Nobuyoshi HiraokaSetsuo Hirohashi
Feb 10, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Noritoshi KobayashiSetsuo Hirohashi
Feb 26, 2009·Nature Reviews. Immunology·David L Woodland, Jacob E Kohlmeier
Feb 2, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Donggou HeHui Xu
Dec 15, 2010·International Journal of Cancer. Journal International Du Cancer·Desheng WengJianlin Gong
Feb 26, 2011·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayDonald Maxwell Parkin
Feb 27, 2013·Oncology Reports·Kohei WakatsukiYoshiyuki Nakajima
Jun 19, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Desheng WengJianlin Gong
Aug 2, 2013·Cancer Metastasis Reviews·Nicole Beauchemin, Azadeh Arabzadeh

❮ Previous
Next ❯

Citations

Sep 5, 2020·Journal of Drug Targeting·Lance B AugustinJanet L Schottel
Oct 12, 2018·Journal of Immunology Research·Marco Antonio Hernández-Luna, Rosendo Luria-Pérez

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Adhesion Molecules in the Brain

Cell adhesion molecules found on cell surface help cells bind with other cells or the extracellular matrix to maintain structure and function. Here is the latest research on their role in the brain.