Abstract
Uveitis of unknown etiology is known to occur in association with various systemic disorders. We now report that anterior uveitis (AU) can be produced by T cell immunity to myelin basic protein (BP) and accompanies experimental autoimmune encephalomyelitis (EAE). EAE with AU was induced in Lewis rats by immunization to BP in CFA or by immunization to various BP peptides including the encephalitogenic 71-90 peptide. Slit-lamp biomicroscopy of BP-immunized Lewis rats revealed AU, characterised by inflammation of the iris, in 73% of the eyes. The onset of AU in actively immunized rats varied between days 12 and 26, often appearing after spontaneous remission of the paralysis, the hallmark of EAE. The course of AU was progressive, affecting more than 50% of the surface of the iris in 16 of 29 diseased eyes. Like the paralysis, the AU was self-limiting: within 2 weeks the disease remitted. In addition, AU could be adoptively transferred to naive and irradiated rats by a T cell clone specific for BP peptide 71-90. The present observations are compatible with the idea that AU may be triggered by BP-reactive T cells. The myelinated nerves present in the iris have been shown to contain BP. However, these peripheral nerves would now appe...Continue Reading
References
Jun 1, 1978·Journal of Neurocytology·R E Madrid, H M Wiśniewski
Mar 1, 1976·Experimental Eye Research·A Huhtala
Oct 1, 1992·Journal of Neuroimmunology·H P HartungK V Toyka
Oct 1, 1992·Journal of Neuroimmunology·T Olsson
Sep 1, 1992·The Journal of Experimental Medicine·S LustigD Ben-Nathan
Mar 1, 1992·The British Journal of Ophthalmology·A RothovaA Kijlstra
Feb 1, 1991·Journal of Neuroimmunology·M I MustafaT Olsson
Feb 1, 1991·Ophthalmology·J I LimJ A Goodwin
Feb 1, 1991·Journal of Neuroscience Research·W F HickeyH Kimura
Dec 1, 1986·European Journal of Immunology·H WekerleR Meyermann
Jul 1, 1989·Cleveland Clinic Journal of Medicine·D M MeislerR M Ransohoff
Feb 15, 1987·American Journal of Ophthalmology·E Bloch-Michel, R B Nussenblatt
Mar 1, 1985·The British Journal of Ophthalmology·D M BachmanA B Beckingsale
Feb 1, 1972·American Journal of Diseases of Children·R G Curless, P F Bray
Aug 13, 1983·Lancet·B A SummersM J Appel
Mar 1, 1981·European Journal of Immunology·A Ben-NunI R Cohen
Jan 1, 1984·Neurochemical Research·J L TrotterW W Tourtellotte
May 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·R A LaursenM B Lees
Jan 7, 1983·Science·J HoloshitzI R Cohen
Apr 1, 1980·Ophthalmology·C A PuliafitoD M Albert
Aug 7, 1980·Nature·J T RosenbaumP R Egbert
Jun 1, 1993·European Journal of Immunology·C LiningtonH Wekerle
May 1, 1970·FEBS Letters·H HirshfeldM Sela
Mar 1, 1958·A.M.A. Archives of Ophthalmology·S J BULLINGTON, B H WAKSMAN
Nov 1, 1960·Archives of Ophthalmology·B H WAKSMAN, S J BULLINGTON
Citations
Aug 24, 1999·Springer Seminars in Immunopathology·J T RosenbaumS R Planck
Jul 7, 2001·Journal of the Neurological Sciences·S SchmidtT Klockgether
Jul 20, 2000·Journal of Neuroimmunology·G AdamusH Offner
Feb 13, 2001·Journal of Neuroimmunology·G AdamusP A Hargrave
Nov 14, 1997·Journal of Neuroimmunology·F X WeilbachG Giegerich
Mar 4, 2000·Journal of Neuroimmunology·M ZhangI Gery
Oct 6, 2001·Progress in Retinal and Eye Research·M D de Smet, C C Chan
Nov 16, 2002·Progress in Retinal and Eye Research·Stephan R Thurau, Gerhild Wildner
Nov 14, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Martin B WaxDavid J Calkins
Nov 10, 2009·Clinical Ophthalmology·Friederike MackensenMatthias D Becker
Nov 6, 2002·Journal of Neuroimmunology·Hui ShaoDeming Sun
Dec 17, 2008·International Review of Cell and Molecular Biology·Andrei Surguchov
Aug 10, 2016·Acta Neuropathologica Communications·Bleranda ZekaMonika Bradl
May 12, 2005·Journal of Neuroimmunology·Hui ShaoDeming Sun
Nov 12, 2002·International Reviews of Immunology·Grazyna Adamus, Chi-Chao Chan
Dec 24, 1997·Journal of Neuroscience Research·G AdamusH Offner
Mar 10, 2001·Journal of Neuroscience Research·H VillarroyaF Eclancher
Dec 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Felix MorIrun R Cohen
Jul 21, 1998·Brain Pathology·P HuT Chan-Ling
Jun 15, 1996·Journal of Neuroscience Research·G AdamusH Offner
Jun 22, 2005·Survey of Ophthalmology·John H ChangDenis Wakefield