T cell immunity to myelin basic protein induces anterior uveitis in Lewis rats

Journal of Neuroimmunology
C VerhagenI R Cohen

Abstract

Uveitis of unknown etiology is known to occur in association with various systemic disorders. We now report that anterior uveitis (AU) can be produced by T cell immunity to myelin basic protein (BP) and accompanies experimental autoimmune encephalomyelitis (EAE). EAE with AU was induced in Lewis rats by immunization to BP in CFA or by immunization to various BP peptides including the encephalitogenic 71-90 peptide. Slit-lamp biomicroscopy of BP-immunized Lewis rats revealed AU, characterised by inflammation of the iris, in 73% of the eyes. The onset of AU in actively immunized rats varied between days 12 and 26, often appearing after spontaneous remission of the paralysis, the hallmark of EAE. The course of AU was progressive, affecting more than 50% of the surface of the iris in 16 of 29 diseased eyes. Like the paralysis, the AU was self-limiting: within 2 weeks the disease remitted. In addition, AU could be adoptively transferred to naive and irradiated rats by a T cell clone specific for BP peptide 71-90. The present observations are compatible with the idea that AU may be triggered by BP-reactive T cells. The myelinated nerves present in the iris have been shown to contain BP. However, these peripheral nerves would now appe...Continue Reading

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Citations

Aug 24, 1999·Springer Seminars in Immunopathology·J T RosenbaumS R Planck
Mar 4, 2000·Journal of Neuroimmunology·M ZhangI Gery
Oct 6, 2001·Progress in Retinal and Eye Research·M D de Smet, C C Chan
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Nov 14, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Martin B WaxDavid J Calkins
Nov 10, 2009·Clinical Ophthalmology·Friederike MackensenMatthias D Becker
Dec 17, 2008·International Review of Cell and Molecular Biology·Andrei Surguchov
Aug 10, 2016·Acta Neuropathologica Communications·Bleranda ZekaMonika Bradl
Nov 12, 2002·International Reviews of Immunology·Grazyna Adamus, Chi-Chao Chan
Dec 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Felix MorIrun R Cohen
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Jun 22, 2005·Survey of Ophthalmology·John H ChangDenis Wakefield

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