T cell independence of macrophage and natural killer cell infiltration, cytokine production, and endothelial activation during delayed xenograft rejection

Transplantation
D CandinasW W Hancock

Abstract

Rejection of guinea pig cardiac grafts in rats depleted of complement takes place in 3-4 days and involves progressive mononuclear cell infiltration and cytokine expression, fibrin and antibody deposition, and endothelial cell up-regulation of adhesion and procoagulant molecules, a process termed delayed xenograft rejection (DXR). The relative contribution of each effector mechanism and the role of T cells in this complex process are unknown, although small numbers of interleukin (IL) 2 receptor-positive T cells are present at the time of rejection. We investigated the importance of T cells in DXR by comparing discordant xenograft responses of nude rats, which lack T cell receptor (TCR)-alpha/beta+ cells, with those of normal Lewis rats. Nude or Lewis rats receiving guinea pig cardiac grafts were assigned to one of three groups: no therapy, daily administration of cobra venom factor (CVF), or splenectomy plus daily CVF. All untreated rats rejected their xenografts within 10-15 min, whereas grafts in complement-depleted recipients survived a further 3-4 days; splenectomy had no significant additional effect upon graft survival. Immunohistologic analysis in CVF-treated nude recipients with or without splenectomy showed: (1) consi...Continue Reading

References

Dec 1, 1988·Transplantation·S MiyagawaH Kitamura
Jul 1, 1966·Transplantation·R J Perper, J S Najarian
Sep 1, 1995·Nature Medicine·F H BachW W Hancock
Oct 1, 1994·Immunological Reviews·F H BachW W Hancock
Apr 1, 1993·Transplantation·J R LeventhalA J Matas

❮ Previous
Next ❯

Citations

Aug 11, 2000·Transplantation Proceedings·T ZhangJ Amano
Aug 14, 2003·Molecular Immunology·Tom E Mollnes, Arnt E Fiane
Sep 5, 2002·Veterinary Immunology and Immunopathology·Ana CarrilloJosé Yélamos
Jul 17, 1999·Human Immunology·S BrouardJ P Soulillou
Sep 19, 2003·Chest Surgery Clinics of North America·Thomas K Waddell, Mark D Peterson
Jun 16, 2007·Nature Reviews. Immunology·Yong-Guang Yang, Megan Sykes
Dec 14, 1999·The British Journal of Surgery·S A White, M L Nicholson
Feb 15, 2000·The British Journal of Surgery·B SoinP J Friend
Jul 6, 2001·Scandinavian Journal of Immunology·M K SchneiderJ D Seebach
Dec 22, 1998·The Journal of Experimental Medicine·A H IdrisW M Yokoyama
Mar 7, 2009·Tissue Engineering. Part a·Rohini GuptaMichael V Sefton
Oct 3, 2000·Transplantation·S YiP J O'Connell
Dec 23, 2004·Transplantation·Lorraine A M CardozoAnthony N Warrens
Mar 30, 2006·Transplantation·William H KitchensJoren C Madsen
Nov 27, 2008·Transplantation·Rafia S Al-LamkiJordan S Pober
Dec 16, 2004·Xenotransplantation·Michael A Rees
Apr 18, 2000·Journal of Clinical Pathology·M J GoddardJ Wallwork
Oct 19, 2012·PloS One·Lilli KrausThorsten Lieke
Mar 21, 2009·Current Opinion in Organ Transplantation·Gisella Puga YungJörg D Seebach
Apr 18, 2008·Kidney International·B SprangersA D Billiau
Mar 1, 1997·Kidney International·W W Hancock
Dec 23, 2008·Transplantation Proceedings·A Cadili, N Kneteman
Nov 11, 2008·Transplant Immunology·Shengqiao LiAn D Billiau
Jun 14, 2005·Transplant International : Official Journal of the European Society for Organ Transplantation·Jana PindjákováVladimír Holán

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.