PMID: 9658113Jul 11, 1998Paper

T-Cell-independent immunoglobulin G responses in vivo are elicited by live-virus infection but not by immunization with viral proteins or virus-like particles

Journal of Virology
Eva Szomolanyi-TsudaR M Welsh

Abstract

Immunoglobulin G (IgG) responses to viruses are generally assumed to be T-cell dependent (TD). Recently, however, polyomavirus (PyV) infection of T-cell-deficient (T-cell receptor beta chain [TCR-beta] -/- or TCR-betaxdelta -/-) mice was shown to elicit a protective, T-cell-independent (TI) antiviral IgM and IgG response. A repetitive, highly organized antigenic structure common to many TI antigens is postulated to be important in the induction of antibody responses in the absence of helper T cells. To test whether the repetitive structure of viral antigens is essential and/or sufficient for the induction of TI antibodies, we compared the abilities of three forms of PyV antigens to induce IgM and IgG responses in T-cell-deficient mice: soluble capsid antigens (VP1), repetitive virus-like particles (VLPs), and live PyV. Immunization with each of the viral antigens resulted in IgM production. VLPs and PyV elicited 10-fold-higher IgM titers than VP1, indicating that the highly organized, repetitive antigens are more efficient in IgM induction. Antigen-specific TI IgG responses, however, were detected only in mice infected with live PyV, not in VP1- or VLP-immunized mice. These results suggest that the highly organized, repetitive ...Continue Reading

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Citations

May 23, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·E Szomolanyi-TsudaR L Garcea
Sep 27, 2001·Viral Immunology·J M Moser, A E Lukacher
Oct 7, 2004·The Journal of Clinical Investigation·Eva Szomolanyi-Tsuda, Raymond M Welsh
Jun 23, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Heath M GuayEva Szomolanyi-Tsuda
May 21, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jeroen E J GuikemaJanet Stavnezer
Jun 5, 2010·PLoS Pathogens·Rabinarayan MishraEva Szomolanyi-Tsuda
Jul 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Qizhi YaoChangyi Chen
Apr 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Heath M GuayEva Szomolanyi-Tsuda
Mar 23, 2004·Annual Review of Immunology·Raymond M WelshEva Szomolanyi-Tsuda
Feb 11, 2004·The Journal of Experimental Medicine·Barbara J HebeisThomas H Winkler
Oct 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Byung O LeeTroy D Randall
Aug 19, 2014·The Journal of Gene Medicine·Patricia CmielewskiDavid W Parsons

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