T cell independent secondary antibody responses to the envelope protein of simian immunodeficiency virus.

Retrovirology
Ghulam NabiK Uberla

Abstract

During human (HIV) and simian (SIV) immunodeficiency virus infection, loss of CD4+ T cells and progression to AIDS are associated with a decline in antibody titers to the viral Gag protein, while antibodies to the Env protein remain high, suggesting a T cell independent antibody response to Env. To explore differential regulation of Gag and Env antibody responses, immunocompetent BALB/c and T cell deficient nude mice were immunized with virus like particles (VLP) of simian immunodeficiency virus or adenoviral vectors expressing SIV Gag and Env. High levels of antibodies against Gag and Env could only be induced in immunocompetent mice, but not in the immunodeficient mice. Thus, neither cells expressing Env after adenoviral gene transfer nor VLPs induce a T cell independent primary anti-Env antibody response. However, secondary B cell responses to Env, but not to Gag, were observed in immunodeficient mice after transfer of primed B cells and boosting with VLPs or adenoviral vectors expressing Gag and Env. This T cell independent secondary antibody response to Env was reduced after stimulation with VLPs modified to contain monomeric membrane bound gp130 surface subunit of Env and undetectable after injection of soluble gp130. Mem...Continue Reading

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Citations

Jan 24, 2014·Virologica Sinica·Vladimir Temchura, Matthias Tenbusch
Apr 4, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wenjin FanQingsheng Li
May 18, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Swagata KarClifford M Snapper

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Datasets Mentioned

BETA
M33262.1
AAA61213.1
CAA24524.1

Methods Mentioned

BETA
FCS
ELISA
flow cytometry

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