T-Cell Leukemia/Lymphoma 1 (TCL1): An Oncogene Regulating Multiple Signaling Pathways

Frontiers in Oncology
Francesco PaduanoFrancesco Trapasso

Abstract

Almost 30 years ago, Carlo Croce's group discovered the T-Cell Leukemia/Lymphoma 1A oncogene (TCL1A or TCL1). TCL1 protein is normally expressed in fetal tissues and early developmental stage lymphocytes. Its expression is deregulated in chronic lymphocytic leukemia (B-CLL) and most lymphomas. TCL1 plays a central role in lymphomagenesis as a co-activator of AKT kinases and other recently elucidated interacting protein partners. These include ATM, HSP70 and TP63, which were all confirmed as binding partners of TCL1 from co-immunoprecipitation experiments utilizing endogenously expressed proteins. The nature of these interactions highlighted the role of TCL1 in enhancing multiple signaling pathways, including PI3K and NF-κB. Based on its role in the aforementioned pathways and, despite the lack of a well-defined enzymatic activity, TCL1 is considered a potential therapeutic target for TCL1-positive hematological malignancies. This perspective will provide an overview of TCL1A and its interacting partners.

References

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Citations

May 10, 2019·International Journal of Molecular Sciences·Ken NishimuraKoji Hisatake
Sep 26, 2019·Journal of Cellular Physiology·Maria Teresa FiorenzaArturo Bevilacqua
May 10, 2020·Journal of Integrative Bioinformatics·Vânia Rodrigues, Sérgio Deusdado
Mar 16, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Melissa R PergandeStephanie M Cologna
Oct 1, 2019·Cell Cycle·Maria Teresa Fiorenza, Alessandro Rava
Sep 18, 2020·International Journal of Molecular Sciences·Linda FabrisGeorge Calin
Apr 5, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Siyu Sun, Wenjia Fang
Jul 3, 2021·Cells·François BrinasSophie Brouard
Jun 14, 2020·Blood Reviews·Christine Bellanné-ChantelotIsabelle Plo

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Methods Mentioned

BETA
transgenic
two-hybrid
immunoprecipitation
ubiquitination
protein folding
pull-down
xenografts
phage display

Software Mentioned

PubChem
MMsINC

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