PMID: 6785748Feb 1, 1981Paper

T-Cell lymphoma model for the analysis of interleukin 1-mediated T-cell activation

Proceedings of the National Academy of Sciences of the United States of America
S Gillis, S B Mizel

Abstract

Several laboratories have recently demonstrated that the requirement for macrophages in mitogen-induced production of murine T-cell interleukin 2 (IL-2; formerly referred to as "T-cell growth factor") could be circumvented by using the macrophage-derived peptide interleukin 1 (IL-1; formerly referred to as "lymphocyte-activating factor"). Using two cloned T-cell lymphomas, we investigated the mechanism through which IL-1 exerted its effect on IL-2 production. One of the cell lines used (LBRM-33 5A4) produces large concentrations of IL-2 upon mitogen stimulation, whereas the second (LBRM-33 1A5) is incapable of producing IL-2 in response to mitogen. It was observed that addition of purified IL-1 to nonproducer 1A5 cells converted them to a state in which subsequent mitogen stimulation triggered production of IL-2. The concentration of IL-2 produced by IL-1 treated 1A5 cells was equivalent in magnitude to that generated by mitogen-stimulated 5A4 cells (500-1000 units/ml, or approximately 1000 times the concentration of IL-2 contained in conventional preparations of murine mitogen-conditioned medium). The observations that (i) brief exposure to IL-1 was sufficient for 1A5 cell conversion to IL-2 production and (ii) IL-1 could acti...Continue Reading

References

Jul 14, 1977·Nature·S Gillis, K A Smith
Jun 1, 1979·The Journal of Experimental Medicine·S GillisK A Smith
Oct 1, 1978·The Journal of Experimental Medicine·S GillisK A Smith
Jan 1, 1979·Annals of the New York Academy of Sciences·K A SmithF W Ruscetti
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Citations

Mar 1, 1990·Journal of Cellular Physiology·G B MillsE W Gelfand
Jan 1, 1983·Journal of Clinical Immunology·S Gillis
Jun 1, 1989·Agents and Actions·K A RichardH M Einspahr
Jan 1, 1988·Immunologic Research·G N Gaulton, J F Markmann
Dec 21, 2004·Springer Seminars in Immunopathology·Kenneth L RockYan Shi
Nov 30, 1983·Biochemical and Biophysical Research Communications·S MitaH Ogawa
Jun 13, 1988·Journal of Immunological Methods·N OudrhiriF Reyes
Mar 10, 1989·Journal of Immunological Methods·M K EskandariD G Remick
Jun 21, 1989·Journal of Immunological Methods·S J Hopkins, M Humphreys
Mar 1, 1984·Mechanisms of Ageing and Development·M Bruley-Rosset, I Vergnon
Jan 1, 1985·Comparative Immunology, Microbiology and Infectious Diseases·M Fevrier
Mar 1, 1987·Veterinary Immunology and Immunopathology·D AtluruR D Schultz
Mar 1, 1993·Veterinary Immunology and Immunopathology·S L DanielB T Rouse
Mar 1, 1988·Immunology Letters·R M Steinman
May 1, 1988·Journal of Neuroimmunology·W Gilmore, L P Weiner
Jan 1, 1984·International Journal of Immunopharmacology·J BonaventureC A Brailovsky
Oct 1, 1988·Neuroscience·G T SpearM E Gurney
Jun 17, 2000·Fertility and Sterility·M HuleihelM Glezerman
Nov 22, 2002·American Journal of Reproductive Immunology : AJRI·Mahmoud HuleihelMoshe Mazor
Dec 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·M OkadaT Kishimoto
Jun 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·G A KoretzkyP C Nowell
Oct 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·T R BeardsleyE F Hays
Aug 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·E T ChuR S Geha
Oct 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·R Palacios
Feb 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·S K DowerD L Urdal
Mar 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J P LugoE V Rothenberg
Jul 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·B MosleyD Cosman
Jul 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·R PacificiW A Peck
Nov 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·R D GarmanD H Raulet
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·A H LichtmanA K Abbas
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·R PacificiW A Peck
May 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·S HaskillS Fong

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