T-Cell Lymphomas Presenting as Colon Ulcers and Eosinophilia

Case Reports in Gastroenterology
Ping-Hsiu WuChin-Chu Wu

Abstract

Primary gastrointestinal T-cell lymphoma is an uncommon entity and primary colon T-cell lymphoma is even rarer. The majority of enteropathy-associated T-cell lymphomas present predominantly as ulcers or strictures in the endoscopic examinations, while primary B-cell lymphomas commonly present as exophytic lesions. Ulcerative colon T-cell lymphoma may mimic Crohn's disease (CD), which is a chronic inflammatory disease of the intestines with ulcer and fistula formations difficult for clinicians to diagnose based on endoscopic observations alone. Like CD, T-cell lymphoma may be characterized by the presence of multiple skipped ulcers distributed from the terminal ileum to the descending colon. Furthermore, it is difficult to diagnose this unusual lymphoma by a single endoscopic biopsy. Typically, the histological composition of T-cell lymphoma is made of medium to large atypical cells located in the base of the ulcer with extension to the muscle layer and the adjacent mucosa. However, it is common that biopsy specimens show only mixed inflammatory changes where the lymphoma cells are hard to be identified. The differential diagnosis of malignant lymphoma must be considered when clinically diagnosed CD is refractory to the medical ...Continue Reading

Citations

Aug 3, 2019·Journal of Pathology and Translational Medicine·Ji-Ye KimMee Joo
Oct 27, 2020·Current Opinion in Gastroenterology·Kavea PanneerselvamAnusha Shirwaikar Thomas

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BETA
biopsy
biopsies

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