T-cell-mediated cytotoxic response to mumps virus in humans.

Infection and Immunity
H TsutsumiT Nakao

Abstract

Mumps-specific T-cell-mediated cytotoxic activity against virus-treated autologous lymphocytes was studied after peripheral blood lymphocytes of sensitized subjects had been incubated with ultraviolet light-inactivated virus antigen. Generation of the cytotoxic activity in vitro was associated with an antecedent lymphoproliferative response to mumps virus. The virus specificity of the effector cells was demonstrated by a lack of lysis of type 1 parainfluenza virus (HVJ)-treated as well as of type A influenza virus-treated autologous target cells. This activity was largely associated with E-rosette-forming T lymphocytes as revealed by negative selection of a population from cultured whole lymphocytes. In addition, sequential investigations for subjects with a natural mumps virus infection clearly demonstrated individual characteristics of the cytotoxic response. Therefore, the assay described could be used to reflect mumps virus-specific T-cell-mediated immunity in humans.

References

Mar 1, 1975·American Journal of Epidemiology·J W GemeR Paumier
Dec 1, 1966·Proceedings of the Society for Experimental Biology and Medicine·E B Buynak, M R Hilleman
Aug 1, 1972·The Journal of Clinical Investigation·E M ShevachI Green

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Citations

Jan 1, 1981·Microbiology and Immunology·T Kato, T Minagawa
Apr 1, 1985·Scandinavian Journal of Immunology·A R AlsheikhlyP Perlmann
Oct 1, 1986·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section C, Immunology·H HyötyP Leinikki

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