PMID: 6170699Dec 1, 1981Paper

T cell-mediated cytotoxicity induced by Listeria monocytogenes. II. Specificity of cytolytic effector cells

The Journal of Immunology : Official Journal of the American Association of Immunologists
M C WoanU Forsum

Abstract

Listeria monocytogenes- (LM) antigen-dependent cytotoxic lymphocytes, identified in a companion manuscript as T cells (CTL), can kill a wide variety of target cells, including syngeneic fibroblasts of both fetal and adult origin, and certain allogeneic and xenogeneic tumor cells. Cold target cell inhibition assays revealed that cells susceptible to lysis can block the cytolytic process in a dose-dependent manner, whereas lysis-resistant cells cannot. Several lines of evidence indicate that to realize their cytolytic potential, LM-dependent CTL must bind to their targets. Aggressor cells that adhere to susceptible target cell monolayers have enhanced cytolytic activity when compared with unfractionated cells or cells that do not adhere. LM-dependent CTL fail to kill when they are separated from susceptible targets by an agar barrier. Arguments against the complicity of a soluble mediator in the killing process derive from the rapid (within 3 hr) expression of cytotoxicity in circumstances where cell contact can occur, and the finding that spent medium in which LM-dependent CTL are either activated or assayed is devoid of cytolytic activity. The specificity of LM-dependent CTL suggests that these effector T cells recognize an as ...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.