PMID: 11605990Oct 19, 2001Paper

T cell-mediated immune response enhances the severity of myocarditis in secondary cardiotropic virus infection in mice

Basic Research in Cardiology
C KishimotoH Takada

Abstract

In this report, we showed that a previous enterovirus exposure in ordinary mice with normal T cell function, but not in T cell-deficient mice, can influence development of myocardial inflammation with a second virus exposure. Inoculation of 4-week-old male BALB/c-nu/+ (euthymic and normal T cell function) mice with amyocarditic Coxsackie virus B1 (CB1), followed by inoculation 28 days later with myocarditic variant of Coxsackie virus B3 (CB3-m) resulted in more intense myocardial inflammation and injury than was seen in BALB/c-nu/+ inoculated with CB1, followed by inoculation with non-enterovirus, i.e., encephalomyocarditis virus (EMC) or influenza A virus and in age-matched BALB/c-nu/+ mice secondary inoculated with CB3-m alone. In contrast, this phenomenon of the enhancement of the severity of myocarditis by a secondary CB3-m inoculation was not seen in BALB/c-nu/nu (athymic and T cell- deficient) mice. Interestingly, inoculation of BALB/c-nu/+ mice with CB1, followed by inoculation 28 days later with another amyocarditic variant of Coxsackie virus B3 (CB3-o), resulted in more severe myocarditis than was seen in age-matched BALB/c-nu/+ mice secondary inoculated CB3-o alone. Myocardial-activated T cells and elevated serum inte...Continue Reading

Citations

Jun 15, 2006·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·J HademH Drexler
Apr 4, 2009·Basic Research in Cardiology·Oliver ZimmermannJan Torzewski
Feb 5, 2014·Heart and Vessels·Chiharu KishimotoKagemasa Kuribayashi
Dec 5, 2008·Expert Review of Vaccines·Andreas HenkePeter Wutzler
Jul 3, 2010·Journal of Comparative Pathology·K Doi
Dec 23, 2003·Bone Marrow Transplantation·S ChakrabartiD W Milligan
Aug 17, 2018·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·A K Ajith Kumar, A S Anoop Kumar
Dec 13, 2016·Journal of Cardiovascular Pharmacology·Abdullah KaplanFouad A Zouein

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