PMID: 8971031Dec 1, 1996Paper

T-cell-mediated immunity to lymphocytic choriomeningitis virus in beta2-integrin (CD18)- and ICAM-1 (CD54)-deficient mice

Journal of Virology
J P ChristensenA R Thomsen

Abstract

The T-cell response to lymphocytic choriomeningitis virus was studied in mice with deficient expression of beta2-integrins or ICAM-1. In such mice, the generation of virus-specific cytotoxic T lymphocytes was only slightly impaired and bystander activation was as extensive as that observed in wild-type mice. T-cell-mediated inflammation, assessed as primary footpad swelling and susceptibility to intracerebral infection, was slightly compromised only in beta2-integrin-deficient mice. However, adoptive immunization of mutant mice soon after local infection did reveal a reduced capacity to support the inflammatory reaction, indicating that under conditions of more limited immune activation both molecules do play a role in formation of the inflammatory exudate. Finally, virus control was found to be somewhat impaired in both mutant strains. In conclusion, our results indicate that although LFA-1-ICAM-1 interaction is important for certain aspects of the T-cell-mediated response to viruses, T-cell activation is surprisingly intact in these mutant mice, indicating extensive functional redundancy within cell interaction molecules.

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Citations

Feb 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·J P ChristensenA R Thomsen
Jan 9, 2013·Proceedings of the National Academy of Sciences of the United States of America·Maureen A CoxAllan J Zajac
Jun 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·K SingbartlK Ley
Aug 24, 2005·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Jean-Jacques GovalLaurence de Leval
Oct 29, 2003·Journal of Virology·Andreas N MadsenAllan R Thomsen
Feb 8, 2008·Journal of Virology·Jianfeng DaiErol Fikrig
Mar 3, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Dmitry V OstaninMatthew B Grisham

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