T-Cell Metabolism in Hematopoietic Cell Transplantation

Frontiers in Immunology
Hung D NguyenXue-Zhong Yu

Abstract

Metabolism, including catabolism and anabolism, is a basic cellular process necessary for cell survival. T lymphocytes have a distinct metabolism that can determine both fate and function. T-cell activation depends on glycolysis to obtain materials and energy for proliferation and effector function. Importantly, T cells utilize different metabolic processes under different conditions and diseases. Allogeneic hematopoietic cell transplantation (allo-HCT) is a classic immunotherapy for hematological malignancies; however, the development of graft-versus-host disease (GVHD) is a major factor limiting the success of allo-HCT. T cells in the donor graft drive GVHD by mounting a robust immunological attack against recipient normal tissues. Hence, understanding T-cell metabolism after allo-HCT would provide potential metabolic targets for the control of GVHD and primary tumor relapse. The purpose of the current review is to highlight the key metabolic pathways involved in alloantigen-activated T cells and to discuss how manipulating these pathways can serve as potential new therapeutic strategies to induce immune tolerance after allo-transplantation. We will also summarize the recent progress in regulating T-cell metabolism in bone ma...Continue Reading

References

Jun 5, 1997·Nature·K Simons, E Ikonen
Jul 18, 2002·Immunity·Kenneth A FrauwirthCraig B Thompson
Aug 3, 2004·Nature Reviews. Cancer·Besim Ogretmen, Yusuf A Hannun
Jun 24, 2006·The Journal of Biological Chemistry·Yael Pewzner-JungAnthony H Futerman
Nov 20, 2008·Journal of Lipid Research·Nana Bartke, Yusuf A Hannun
Mar 14, 2009·Lancet·James L M FerraraErnst Holler
Apr 4, 2009·Nature Reviews. Immunology·June L Round, Sarkis K Mazmanian
May 23, 2009·Science·Matthew G Vander HeidenCraig B Thompson
Jun 6, 2009·Nature·Erika L PearceYongwon Choi
Jun 23, 2009·Nature·Koichi ArakiRafi Ahmed
Jan 21, 2010·Physiological Reviews·Gary D LopaschukWilliam C Stanley
Jul 20, 2010·Immunological Reviews·Loise M FranciscoArlene H Sharpe
Jul 31, 2010·Molecular Cell·Katrin DüvelBrendan D Manning
Dec 16, 2010·The FEBS Journal·Ronald J A WandersStephan Kemp
Nov 22, 2011·Nature·Christian M MetalloGregory Stephanopoulos
Feb 22, 2012·Trends in Immunology·Valerie A Gerriets, Jeffrey C Rathmell
May 2, 2012·The Journal of Experimental Medicine·Robert R JenqMarcel R M van den Brink
May 12, 2012·Nature Reviews. Immunology·Bruce R BlazarMehrdad Abedi
Aug 15, 2012·Immunological Reviews·Gerritje J W van der Windt, Erika L Pearce
Sep 20, 2012·Nature Immunology·Ruoning Wang, Douglas R Green
Feb 27, 2013·Immunity·Michael P Murphy, Richard M Siegel
Apr 23, 2013·Immunity·Erika L Pearce, Edward J Pearce
Aug 3, 2013·Pharmacological Reviews·Francisco J Quintana, David H Sherr
Sep 24, 2013·Biochimica Et Biophysica Acta·Wenhui Jiang, Besim Ogretmen
Oct 5, 2013·The Journal of Clinical Investigation·Madhusudhanan SukumarLuca Gattinoni
Oct 12, 2013·Science·Erika L PearceRussell G Jones
Feb 26, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·JangEun LeeYongwon Choi
Aug 16, 2014·The Journal of Pharmacology and Experimental Therapeutics·Gary D GlickAnthony W Opipari

❮ Previous
Next ❯

Citations

Mar 25, 2019·Frontiers in Immunology·Govindarajan Thangavelu, Bruce R Blazar
Aug 1, 2019·World Journal of Transplantation·Omar Domínguez-AmorochoNiels Olsen Saraiva Camara
Mar 7, 2021·Critical Reviews in Oncology/hematology·Wenhui ZhangXiao Xu

❮ Previous
Next ❯

Methods Mentioned

BETA
acetylation

Related Concepts

Related Feeds

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Cellular Immunometabolism

Immunometabolism involves not only the way metabolites are digested by the immune system, but the way in which they can alter the pathway of the immune system. These responses occur in day-to-day healthy cell functioning, but can result in diseases, such as autoimmune disorders. Discover the latest research on cellular immunometabolism here.

Related Papers

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
A Zarrinpar, S J Bensinger
Frontiers in Immunology
Michelle YapNicolas Degauque
© 2022 Meta ULC. All rights reserved