T-cell non-Hodgkin lymphoma in human immunodeficiency virus-1-infected individuals

American Journal of Hematology
J A LustG E Woloschak

Abstract

We present two patients with human immunodeficiency virus-1 (HIV-1) infection in whom T-cell non-Hodgkin lymphoma developed, based on pathologic diagnosis, immunophenotyping, and T-cell receptor gene rearrangement. Both cases were positive for human immunodeficiency virus-1 by enzyme-linked immunosorbent assay and immunoblot methods. Histologic sections from each patient showed a high-grade pleomorphic T-cell non-Hodgkin lymphoma, and immunophenotyping demonstrated a prevalence of reactivity for CD4 (helper) over CD8 (suppressor) antigens. T-cell receptor beta-chain gene rearrangement studies revealed a rearranged pattern with either the HindIII or BamHI enzymes, whereas immunoglobulin heavy chain genes retained a germ-line configuration. Viral sequences specific for human T-cell leukemia virus-I, human T-cell leukemia virus-II, or HIV-1 were not detected. Thus, although rare, T-cell non-Hodgkin lymphoma may be observed in HIV-1-infected individuals.

References

Sep 1, 1987·British Journal of Haematology·M R Howard, B A McVerry
Sep 9, 1983·JAMA : the Journal of the American Medical Association·R L ModlinC R Taylor
Dec 1, 1980·Cancer·S WatanabeT Nagatani

❮ Previous
Next ❯

Citations

Apr 11, 2001·Current Oncology Reports·D J Straus
Aug 16, 2001·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·I T LeongD Mock
Oct 1, 1993·Sangre·M I Rodríguez SalazarF Casanova Valero
Nov 1, 1990·Histopathology
May 1, 1994·Histopathology·C O Bellamy, A S Krajewski
Mar 5, 2013·Archives of Pathology & Laboratory Medicine·Amy ChadburnAmy A Lo
Nov 15, 2005·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jaime A CollinsUNKNOWN Almenara Hospital AIDS Working Group
Jun 1, 1992·American Journal of Hematology·N J MeropolJ S Bennett
Feb 1, 1991·American Journal of Hematology·J E GoldR Zalusky

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.