PMID: 6972987Mar 1, 1981Paper

T cell ontogeny. Organ location of maturing populations as defined by surface antigen markers is similar in neonates and adults

The Journal of Experimental Medicine
J J HaaijmanL A Herzenberg

Abstract

Earlier studies have suggested that splenic T cell populations in nursling mice (less than 18 d of age) have Lyt cell surface antigens that identify them as less mature than their adult counterparts. Studies presented here, however, demonstrate that the expression of the Thy-1, Lyt-1, Lyt-2, and Lyt-3 T cell antigens is virtually identical in 14-d-old and adult T cell populations even though at 14 d, T cells constitute less than 10% of the total spleen cell population. Because the expression of these antigens on the immature (cortical) thymocyte population differs substantially from their expression on peripheral T cells, the maturity of splenic T cells as judged by these criteria is similar in nurslings and adults. Very few cells in the neonatal thymus 4 h after birth correspond, in terms of antigen expression, to the more mature (medullary) thymocyte population of adults, but such cells develop rapidly during the first few days of life. They are present, therefore, sufficiently early to serve as the immediate source of peripheral T cells, as they apparently do in the adult. This then suggests that the locations for the major T cell maturational events are established within the first 2 wk of life of the mouse and maintained a...Continue Reading

References

Jan 1, 1979·Immunological Reviews·J A Ledbetter, L A Herzenberg
Aug 5, 1976·Nature·P C BeverleyI McKenzie
Jan 1, 1975·Cellular Immunology·C G FathmanI L Weissman
Feb 1, 1973·The Journal of Experimental Medicine·I L Weissman

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Citations

Nov 1, 1985·Developmental Biology·E Rothenberg, J P Lugo
Dec 1, 1991·Immunology and Cell Biology·M Lipoldová, V Holán
Sep 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·B A KyewskiH S Kaplan
Jan 1, 1983·The Journal of Experimental Medicine·K HayakawaL A Herzenberg
Apr 1, 1983·American Journal of Reproductive Immunology : AJRI·E K Main, C W Pierce
Jun 1, 1985·Cell Biophysics·T N Buican, G W Hoffmann
May 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ioannis ChatzidakisClio Mamalaki
Jan 1, 1982·Journal of Immunological Methods·J L Dangl, L A Herzenberg

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