Abstract
This study was undertaken to determine which if any pretreatment factors are statistically significant determinants of the clinical outcome in patients with non-Hodgkin's lymphoma. The pretreatment factors in 20 patients with T-cell lymphoma, including two patients with adult T-cell leukemia/lymphoma (ATLL), and 28 patients with B-cell lymphoma were evaluated. In a stepwise logistic regression analysis, a T-cell phenotype in addition to high grade histology and pleural involvement demonstrated a statistically significant correlation with decreased response rate, when the analysis did not include patients with ATLL. Analysis by means of the Cox proportional hazards model disclosed that the T-cell phenotype retained a statistically significant correlation with survival after adjustments for other prognostic factors, whether the study included the patients with ATLL or not. The decreased response rate and survival of Japanese patients with non-Hodgkin's lymphoma in comparison with those reported in Western countries seem to be due to increased intrusion of T-cell lymphomas. To permit a reliable comparison of reports on new chemotherapeutic regimens from different institutions, the tumor phenotype must be determined in the populati...Continue Reading
References
Sep 1, 1979·Acta Pathologica Japonica·T SuchiS Fukunaga
Jul 1, 1985·Annals of Internal Medicine·M Coleman
May 1, 1985·Annals of Internal Medicine·P Klimo, J M Connors
Jun 1, 1989·American Journal of Clinical Oncology·K ShimizuA Kunii
Jan 1, 1988·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M ShimoyamaS Tominaga
Jul 1, 1988·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M ShimoyamaK Minato
Mar 1, 1985·American Journal of Clinical Pathology·T M GroganS Jones
Oct 1, 1988·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B CoiffierJ P Magaud
Sep 1, 1986·American Journal of Clinical Pathology·K ShimizuA Kunii
Sep 1, 1983·Human Pathology·M E KadinH Wakasa
Jul 1, 1984·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J P GreerR S Stein
Mar 1, 1983·Annals of Internal Medicine·R I FisherR C Young
Jan 1, 1982·International Urology and Nephrology·J SzöllösiM Sas
Citations
Jan 1, 1991·Leukemia & Lymphoma·D M MtasiwaA Kuramoto
Jul 1, 1993·Leukemia & Lymphoma·M ShimoyamaM Narabayashi
Jan 1, 1991·Leukemia Research·P M ChenT J Chiou
May 1, 1992·Hematological Oncology·R LiangA C Chan
May 1, 1992·Hematological Oncology·R LiangS L Loke
Nov 1, 1991·Hematological Oncology·S CauletJ Diebold