PMID: 7540654Jul 1, 1995Paper

T cell priming versus T cell tolerance induced by synthetic peptides

The Journal of Experimental Medicine
P AicheleH Pircher

Abstract

It is well known that synthetic peptides are able to both induce and tolerize T cells. We have examined the parameters leading either to priming or tolerance of CD8+ cytotoxic T lymphocytes (CTL) in vivo with a major histocompatibility complex class I (H-2 Db) binding peptide derived from the glycoprotein (GP aa33-41) of lymphocytic choriomeningitis virus (LCMV). By varying dose, route, and frequency of LCMV GP peptide application, we found that a single local subcutaneous injection of 50-500 micrograms peptide emulsified in incomplete Freund's adjuvant protected mice against LCMV infection, whereas repetitive and systemic intraperitoneal application of the same dose caused tolerance of LCMV-specific CTL. The peptide-induced tolerance was transient in euthymic mice but permanent in thymectomized mice. These findings are relevant for a selective use of peptides as a therapeutic approach: peptide-induced priming of T cells for vaccination and peptide-mediated T cell tolerance for intervention in immunopathologies and autoimmune diseases.

References

Feb 1, 1975·The Australian Journal of Experimental Biology and Medical Science·K J Lafferty, A J Cunningham
Aug 1, 1992·Current Opinion in Immunology·R Arnon, R J Horwitz
May 1, 1990·The Journal of Experimental Medicine·P AicheleM Schulz
Mar 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·W M KastC J Melief
Feb 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·M SchulzH Hengartner
Mar 1, 1989·The Journal of Experimental Medicine·F R Carbone, M J Bevan
Jan 1, 1986·Annual Review of Immunology·H S WarrenL A Chedid
Sep 1, 1994·Immunity·M K Jenkins
Jun 7, 1994·Proceedings of the National Academy of Sciences of the United States of America·L VidardB Benacerraf
Oct 1, 1993·International Immunology·C MamalakiD Kioussis
Jan 18, 1994·Proceedings of the National Academy of Sciences of the United States of America·R Tisch, H O McDevitt
Jan 18, 1994·Proceedings of the National Academy of Sciences of the United States of America·P AicheleH Pircher
Aug 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·T J BrinerJ L Greenstein
Dec 15, 1964·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·N A MITCHISON

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Citations

Sep 25, 1999·International Journal of Cancer. Journal International Du Cancer·L H BrinckerhoffC L Slingluff
Aug 17, 2000·Springer Seminars in Immunopathology·H WagnerG B Lipford
Mar 20, 1999·Transplantation Proceedings·T E StarzlA Rao
May 17, 2003·Bulletin of Mathematical Biology·Can Keşmir, Rob J De Boer
Dec 14, 2001·Molecular Immunology·I P HunzikerA Cerny
Apr 6, 1999·Pharmacology & Therapeutics·B R MinevM S Mitchell
Mar 24, 2000·Progress in Lipid Research·R ZurbriggenR Glück
Dec 5, 1997·Immunology Today·W O Weigle, C G Romball
Jan 13, 1998·Immunology Today·R LiblauH O McDevitt
Apr 12, 2000·Trends in Biotechnology·P JohansenD Sesardic
Oct 26, 2001·Current Opinion in Immunology·B LudewigR M Zinkernagel
Oct 1, 1996·Current Opinion in Immunology·C J MeliefW M Kast
Apr 27, 2000·Critical Reviews in Oncology/hematology·A J Bremers, G Parmiani
Nov 1, 1996·Immunotechnology : an International Journal of Immunological Engineering·M E RessingC J Melief
Oct 11, 2003·Autoimmunity Reviews·Philippe KrebsBurkhard Ludewig
Feb 23, 2010·Asian Journal of Andrology·Maja M Kosanović, Miroslava M Janković
Aug 1, 1997·Immunology and Cell Biology·A Suhrbier
May 19, 1998·Nature Medicine·D M Pardoll
May 11, 2002·Nature Reviews. Immunology·Andrew McMichael, Tomâs Hanke
Jul 10, 2003·Immunology and Cell Biology·Martin S StaegeAngelika B Reske-Kunz
Nov 21, 2000·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·N IchikawaN Murase
Dec 24, 1998·The New England Journal of Medicine·T E Starzl, R M Zinkernagel
Apr 1, 2009·Proceedings of the National Academy of Sciences of the United States of America·Gullu GorgunJohn G Gribben
Jul 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·R E ToesW M Kast
Aug 1, 1996·The Journal of Experimental Medicine·M A Alexander-MillerJ A Berzofsky
Sep 19, 2001·The Journal of Experimental Medicine·D HawigerM C Nussenzweig
Oct 23, 2002·The Journal of Experimental Medicine·Kang LiuRalph M Steinman
Jun 6, 2002·Journal of the National Cancer Institute·Giorgio ParmianiAndrea Anichini
Jul 29, 2003·Transplantation·Yoichi MaekawaKoji Yasutomo
Oct 3, 1998·Experimental Dermatology·G De Panfilis
Aug 1, 1996·Immunological Reviews·P AicheleR M Zinkernagel
Apr 9, 2001·Clinical Microbiology Reviews·P L OgraR C Welliver

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