T-cell receptor alpha beta and gamma delta T cells in rat and human skin--are they equivalent?

Seminars in Immunology
A ElbeG Stingl

Abstract

In the not-so-distant past the skin was generally viewed as a passive target for immune-mediated injury. Over the last decade, however, concepts of a previously unrecognized role for the skin have unfolded, whereby resident bone marrow-derived leukocytes (e.g. Langerhans cells and T cells) initiate and regulate the immune responses that protect it. Their combination with other immunomodulatory resident cells (e.g. keratinocytes, melanocytes, endothelial cells, fibroblasts) led to the idea that the skin may function as a self-sustaining lymphoid tissue. Although T lymphocytes or, at least, certain subpopulations thereof have the general propensity to populate epithelial tissues, there exist major species differences regarding the phenotype of intraepidermal T cells. The purpose of this review is to fill gaps in our understanding of the relationship of rodent skin T cells to T cells identified in human skin and the normal physiologic and pathologic role(s) of these cells.

Citations

May 5, 2004·The Journal of Experimental Medicine·Patrick SchaerliBernhard Moser
Sep 19, 2017·Nature Reviews. Immunology·Morten M NielsenWendy L Havran
Mar 2, 2006·International Immunology·Jill C GraffMark A Jutila
Apr 25, 2019·International Journal of Molecular Sciences·Alan V Nguyen, Athena M Soulika
Feb 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Javier Mestas, Christopher C W Hughes
Jan 23, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Amanda S Woodward DavisMichael J Bevan
Aug 5, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ute LaggnerFrank O Nestle
Mar 18, 2016·Oncology Reports·Monica NeaguAristidis M Tsatsakis
Feb 7, 2019·Journal of Immunology Research·Abigail S MarshallNader Ghasemlou
Jul 7, 2017·Disease Models & Mechanisms·Nicklas Heine StaunstrupJacob Giehm Mikkelsen
Oct 28, 2008·Burns : Journal of the International Society for Burn Injuries·Martin G Schwacha

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