T-cell receptor bias and immunity

Current Opinion in Immunology
Stephanie GrasJamie Rossjohn

Abstract

Despite the potentially vast T-cell repertoire, biased alphabeta T-cell receptor (TCR) usage has emerged as a common theme in immunity. Examples of TCR bias are observed in classical polymorphic major histocompatibility complex (MHC)-restricted immune responses as well as in T-cell responses to non-classical, monomorphic Ag-presenting molecules, such as CD1d. Recent data have implicated the structural landscape of these antigen-presenting molecules as one of the drivers of TCR bias. Here we review recent advances in the field, focussing on structural data pertaining to biased TCR usage, and discuss the implications for T-cell repertoire selection, MHC restriction and therapeutic development.

References

Apr 19, 1984·Nature·P MatzingerH Waldmann
Jan 1, 1994·The Journal of Experimental Medicine·E P RockY H Chien
Jun 11, 2003·Nature Immunology·Guillaume B E Stewart-JonesE Yvonne Jones
Nov 17, 2005·The Journal of Experimental Medicine·David A PriceDaniel C Douek
Feb 14, 2006·Nature Immunology·Hilary L HoareAndrew G Brooks
Mar 23, 2006·Annual Review of Immunology·Markus G RudolphIan A Wilson
Apr 18, 2006·Proceedings of the National Academy of Sciences of the United States of America·Lauren K ElyJamie Rossjohn
Nov 18, 2006·Nature Reviews. Immunology·Stephen J TurnerJamie Rossjohn
Nov 30, 2006·Proceedings of the National Academy of Sciences of the United States of America·Vanessa VenturiMiles P Davenport

❮ Previous
Next ❯

Citations

Feb 22, 2012·Cancer Immunology, Immunotherapy : CII·Kimberly R JordanJill E Slansky
Sep 26, 2012·Journal of Mathematical Biology·Grzegorz A Rempala, Michal Seweryn
Jan 4, 2012·Cell Research·Hanjie LiJiahuai Han
Jan 17, 2009·Nature Immunology·K Christopher GarciaLauren K Ely
Aug 8, 2009·Nature Medicine·Carey N LumengAlan R Saltiel
Dec 3, 2008·Proceedings of the National Academy of Sciences of the United States of America·Katherine KedzierskaStephen J Turner
Mar 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Alex TheodossisJamie Rossjohn
May 21, 2010·Proceedings of the National Academy of Sciences of the United States of America·Scott R BurrowsJamie Rossjohn
Jun 23, 2010·The Journal of Experimental Medicine·Stephanie GrasScott R Burrows
Mar 14, 2012·The Journal of Experimental Medicine·Rangsima ReantragoonJames McCluskey
Apr 30, 2014·Nature Structural & Molecular Biology·Jan PetersenJamie Rossjohn
Jan 30, 2014·Proceedings of the National Academy of Sciences of the United States of America·Tania CukalacNicole L La Gruta
Mar 30, 2013·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Aaron W Michels
Sep 3, 2013·Current Opinion in Immunology·Sidonia B G EckleJames McCluskey
Jun 16, 2009·Current Opinion in Immunology·Stephen J TurnerPeter C Doherty
Mar 6, 2009·Cellular Immunology·Heli TuovinenT Petteri Arstila
Jan 8, 2009·Immunology·Linda WooldridgeAndrew K Sewell
Jul 16, 2013·Current Opinion in Virology·Nicole L La Gruta, Paul G Thomas
Jan 27, 2009·Immunity·Stephanie GrasJamie Rossjohn
Apr 26, 2016·The Journal of Clinical Investigation·Daniela BenatiLisa A Chakrabarti
Oct 11, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Madhura MukhopadhyayLisa A Chakrabarti
Apr 11, 2018·Nature Reviews. Immunology·Nicole L La GrutaJamie Rossjohn
Jun 23, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stéphanie GrasDominique Housset
Feb 11, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rebekah M BrennanScott R Burrows
Dec 24, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·E Bridie ClemensStephen J Turner
Apr 22, 2016·International Journal of Oncology·Chun-Yan WangZhi-Zhong Jing
Aug 8, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Vanessa VenturiMiles P Davenport
Jul 25, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hanjie LiJiahuai Han
Apr 7, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Petra BesgenJoerg Christoph Prinz
Dec 6, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stephanie GrasJamie Rossjohn
Oct 31, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Usha K NivarthiMandvi Bharadwaj

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.