Oct 19, 1989

T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1

Nature
M L Dustin, T A Springer

Abstract

Effective interaction between T cells and their targets requires that recognition of specific antigen be coordinated with increased cell-cell adhesion. We show that antigen-receptor cross-linking increases the strength of the adhesion mechanism between lymphocyte function-associated molecule-1 (LFA-1) and intercellular adhesion molecules (ICAMs), with intracellular signals transmitted from the T-cell antigen receptor to the LFA-1 adhesion molecule. The increase in avidity is rapid and transient, providing a dynamic mechanism for antigen-specific regulation of lymphocyte adhesion and de-adhesion.

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  • Citations835

Citations

Mentioned in this Paper

Colforsin
ITGB2 wt Allele
Plant alkaloid
T-Lymphocyte
ITGB2 gene
Protoplasm
ITGAL gene
Lymphocyte Function-Associated Antigen-1
1-Methyl-3-isobutylxanthine
Staurosporine

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