PMID: 9166426Jun 2, 1997Paper

T cell receptor-gamma/delta cells protect mice from herpes simplex virus type 1-induced lethal encephalitis

The Journal of Experimental Medicine
R SciammasJ A Bluestone

Abstract

Increased numbers of T cell receptor (TCR)-gamma/delta cells have been observed in animal models of influenza and sendai virus infections, as well as in patients infected with human immunodeficiency virus and herpes simplex virus type 1 (HSV-1). However, a direct role for TCR-gamma/delta cells in protective immunity for pathogenic viral infection has not been demonstrated. To define the role of TCR-gamma/delta cells in anti-HSV-1 immunity, TCR-alpha-/- mice treated with anti- TCR-gamma/delta monoclonal antibodies or TCR-gamma/delta x TCR-alpha/beta double-deficient mice were infected with HSV-1 by footpad or ocular routes of infection. In both models of HSV-1 infection, TCR-gamma/delta cells limited severe HSV-1-induced epithelial lesions and greatly reduced mortality by preventing the development of lethal viral encephalitis. The observed protection resulted from TCR-gamma/delta cell-mediated arrest of both viral replication and neurovirulence. The demonstration that TCR-gamma/delta cells play an important protective role in murine HSV-1 infections supports their potential contribution to the immune responses in human HSV-1 infection. Thus, this study demonstrates that TCR-gamma/delta cells may play an important regulatory rol...Continue Reading

References

Dec 1, 1979·Infection and Immunity·J F MetcalfR W Reichert
Jan 1, 1977·Survey of Ophthalmology·P S Binder
Jan 1, 1992·The Journal of Experimental Medicine·K HiromatsuK Nomoto
Oct 1, 1990·The Journal of Experimental Medicine·S R CardingP C Doherty
Nov 1, 1989·The Journal of Experimental Medicine·T Goodman, L Lefrancois
Apr 1, 1987·The Journal of Infectious Diseases·A Simmons, A A Nash
Jan 4, 1994·Proceedings of the National Academy of Sciences of the United States of America·M TsujiS Tonegawa
Jan 1, 1994·Cellular Immunology·C AgostiniG Semenzato
Jan 1, 1993·Annual Review of Immunology·W HaasS Tonegawa
Jan 1, 1996·Infection and Immunity·E C Santos Lima, P Minoprio
Jan 1, 1995·Annual Review of Cell and Developmental Biology·J A BluestoneA I Sperling

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Citations

Dec 16, 2000·Springer Seminars in Immunopathology·C T MoritaM B Brenner
Dec 16, 2000·Springer Seminars in Immunopathology·D A WitherdenW L Havran
Dec 16, 2000·Springer Seminars in Immunopathology·D A FerrickB L Beaman
Mar 31, 2004·Medical Hypotheses·Jane TeasPaul V Zimba
Oct 9, 2002·The American Journal of Pathology·Ajai A Dandekar, Stanley Perlman
Nov 24, 1999·Immunology Letters·E RakaszR G Lynch
Aug 30, 2000·Microbes and Infection·S P DeshpandeB T Rouse
Dec 14, 1999·Microbes and Infection·C T MoritaE Märker-Hermann
May 9, 2000·Microbes and Infection·R Sciammas, J A Bluestone
May 9, 2000·Microbes and Infection·J DéchanetJ F Moreau
Jun 26, 2013·Immunology and Cell Biology·Daniel W FowlerMark D Bodman-Smith
May 30, 2002·Nature Reviews. Immunology·Simon R Carding, Paul J Egan
Mar 21, 1998·The Journal of Experimental Medicine·K GoldsmithR L Hendricks
Mar 23, 2000·The Journal of Experimental Medicine·F M SpadaM B Brenner
Oct 11, 2005·Viral Immunology·Vilma DecmanRobert L Hendricks
Jan 13, 2009·Clinical Microbiology Reviews·Tania Crough, Rajiv Khanna
Feb 12, 2002·Journal of Virology·Alana M Thackray, Raymond Bujdoso
Jun 24, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Chun-Shiang ChungAlfred Ayala
Nov 7, 2001·The Journal of Clinical Investigation·L WangJ F Bukowski
Nov 9, 2005·The Journal of Clinical Investigation·Jean-Pierre de VillartayFrançoise Le Deist
May 20, 1999·The Journal of Clinical Investigation·J DéchanetJ F Moreau
Apr 30, 2003·Proceedings of the National Academy of Sciences of the United States of America·Arati B KamathJack F Bukowski
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Georges M G M VerjansAlbert D M E Osterhaus
Oct 12, 2001·Acta Ophthalmologica Scandinavica·T InoueK Hayashi

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