T cell receptor signaling that regulates the development of intrathymic natural regulatory T cells.

Immune Network
Ki-Duk SongCheol-Heui Yun

Abstract

T cell receptor (TCR) signaling plays a critical role in T cell development, survival and differentiation. In the thymus, quantitative and/or qualitative differences in TCR signaling determine the fate of developing thymocytes and lead to positive and negative selection. Recently, it has been suggested that self-reactive T cells, escape from negative selection, should be suppressed in the periphery by regulatory T cells (Tregs) expressing Foxp3 transcription factor. Foxp3 is a master factor that is critical for not only development and survival but also suppressive activity of Treg. However, signals that determine Treg fate are not completely understood. The availability of mutant mice which harbor mutations in TCR signaling mediators will certainly allow to delineate signaling events that control intrathymic (natural) Treg (nTreg) development. Thus, we summarize the recent progress on the role of TCR signaling cascade components in nTreg development from the studies with murine model.

References

Jan 1, 1994·Annual Review of Immunology·E Robey, B J Fowlkes
Jun 8, 1999·Annual Review of Immunology·W EllmeierD R Littman
Feb 28, 2002·Annual Review of Immunology·Lawrence E Samelson
Jul 3, 2002·Nature Reviews. Immunology·Martin Turner, Daniel D Billadeau
Sep 11, 2002·Seminars in Immunology·Alison M Michie, Juan Carlos Zúñiga-Pflücker
Nov 5, 2002·Annual Review of Immunology·Timothy K StarrKristin A Hogquist
Mar 22, 2003·Science·Guy WerlenEd Palmer
Dec 30, 2003·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Connie L SommersPaul E Love
Mar 30, 2005·Proceedings of the National Academy of Sciences of the United States of America·Yisong Y Wan, Richard A Flavell
May 12, 2005·Current Opinion in Immunology·Victor L J Tybulewicz
Oct 6, 2005·The Journal of Experimental Medicine·Jason D FontenotAlexander Y Rudensky
Dec 29, 2005·The Journal of Experimental Medicine·Surapong KoonpaewWeiguo Zhang
Dec 1, 2006·Nature Immunology·Jeong M KimAlexander Y Rudensky
Nov 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jane E WilloughbyRichard Treisman
Jan 18, 2008·Immunity·Chan-Wang Joaquim Lio, Chyi-Song Hsieh
Apr 22, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xiaoxi ChenHung-Sia Teh
May 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Stephan SauerMatthias Merkenschlager
Mar 18, 2009·Immunological Reviews·Byron B Au-YeungArthur Weiss
Jul 18, 2009·European Journal of Immunology·Diana Ordoñez-RuedaGloria Soldevila
Nov 12, 2009·European Journal of Immunology·Alusha A MamchakAnthony L DeFranco
Feb 4, 2010·The Journal of Experimental Medicine·Guoping FuRenren Wen
Feb 5, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mariana I ChuckWeiguo Zhang
Jul 21, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Satoshi TanakaShimon Sakaguchi
Dec 15, 2010·Current Opinion in Immunology·Chan-Wang J Lio, Chyi-Song Hsieh
Jan 19, 2011·Current Opinion in Immunology·Nicholas R J Gascoigne, Ed Palmer
Apr 15, 2011·Immunological Reviews·Guoyan ChengThomas R Malek
Sep 29, 2011·The Journal of Experimental Medicine·Céline ColaciosAbdelhadi Saoudi

❮ Previous
Next ❯

Citations

Mar 20, 2013·BioMed Research International·María Guadalupe Reyes García, Fernando García Tamayo
Oct 3, 2012·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·J Luis EspinozaUNKNOWN Japan Marrow Donor Program

❮ Previous
Next ❯

Methods Mentioned

BETA
nucleotide exchange

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.