PMID: 7540651Jul 1, 1995Paper

T cell receptor V beta repertoire in an acute infection of rhesus monkeys with simian immunodeficiency viruses and a chimeric simian-human immunodeficiency virus

The Journal of Experimental Medicine
Z W ChenN L Letvin

Abstract

Changes in T cell receptor (TCR) V beta repertoire and their correlation with virologic events were investigated in rhesus monkeys after acute infection with the simian immunodeficiency virus (SIV). 11 genetically defined rhesus monkeys were experimentally infected with SIVmac or a chimeric simian-human immunodeficiency virus (SHIV), and their peripheral blood lymphocytes (PBL) and lymph nodes were prospectively assessed for TCR V beta gene expression. PBL and lymph nodes of the acutely infected monkeys demonstrated an expansion of selected V beta-expressing T lymphocyte subpopulations as early as 3 d after infection. These expanded V beta-expressing lymphocyte subpopulations were comprised predominantly of CD8+ cells. Six of seven infected monkeys sharing a single electrophoretically defined major histocompatibility complex class I allele exhibited a similar expansion of V beta 14-expressing PBL. Sequence analyses of V-D-J segments of TCR-beta cDNA indicated that the V beta-expressing T cell subpopulation expansion can be oligoclonal. SIVmac-specific CD8+ cytotoxic T lymphocytes were demonstrated in both PBL and lymph nodes of the infected monkeys at the time expansion of the selected V beta-expressing cell subpopulations was ...Continue Reading

References

Apr 4, 1991·The New England Journal of Medicine·S J ClarkG M Shaw
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Sep 1, 1990·Immunology Today·N L Letvin
Aug 2, 1994·Proceedings of the National Academy of Sciences of the United States of America·Z W ChenN L Letvin
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Citations

Jul 2, 1999·Springer Seminars in Immunopathology·M F Callan, A J McMichael
Jan 1, 1996·Springer Seminars in Immunopathology·C CiurliH Soudeyns
Mar 1, 1996·Immunology Today·M WestbyA G Dalgleish
Aug 11, 2001·Current Opinion in Immunology·D H Barouch, N L Letvin
Aug 1, 1996·Current Opinion in Immunology·R P Johnson
Jun 10, 2009·Immunology and Cell Biology·Hui Yee GreenawayVanessa Venturi
Aug 1, 1996·Nature Medicine·M F CallanA J McMichael
Apr 30, 1996·Proceedings of the National Academy of Sciences of the United States of America·C GraziosiA S Fauci
Jun 6, 1998·The Journal of Experimental Medicine·A J McMichael, C A O'Callaghan
Aug 26, 1998·The Journal of Experimental Medicine·J D WilsonA J McMichael
Jan 1, 1996·AIDS Research and Human Retroviruses·M P D'Souza, B J Mathieson
Apr 21, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·D J MossR Khanna
Feb 28, 2002·Annual Review of Immunology·Norman L LetvinDavid C Montefiori
Jan 7, 1997·Proceedings of the National Academy of Sciences of the United States of America·G PantaleoA S Fauci
Oct 27, 2006·Proceedings of the National Academy of Sciences of the United States of America·Kazuya KamadaAkio Adachi
Sep 2, 1997·Proceedings of the National Academy of Sciences of the United States of America·G PantaleoA S Fauci
Jul 5, 2005·Expert Opinion on Investigational Drugs·M ClericiD Trabattoni
Apr 4, 2008·Reviews in Medical Virology·Masako NomaguchiAkio Adachi
Apr 6, 2001·Virology·M S LapatschekT Miethke
Aug 2, 2015·Vaccine·Hiroshi Ishii, Tetsuro Matano
Jan 24, 2015·Trends in Microbiology·Jonathan M CarlsonZabrina L Brumme
Jul 2, 2003·Nature Medicine·Norman L Letvin, Bruce D Walker

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