PMID: 6170713Nov 1, 1981Paper

T cell receptors with allo-major histocompatibility complex specificity from rat and mouse. Similarity of size, plasmin susceptibility, and localization of antigen-binding region

The Journal of Experimental Medicine
H Binz, H Wigzell

Abstract

Antisera specific for the constant part Ctau of T cell receptor molecules in mice and rats have been produced in rabbits by immunization with idiotype-positive rat T cell molecules. Such antisera could be shown to react with the majority of normal T lymphocytes from both rats and mice. Mixed leukocyte culture-activated T blasts displayed a higher percentage of positive cells than concanovalin A- or phytohemaglutinin-induced T blasts. Lipopolysaccharide-induced B blasts were not reactive with the antiserum. Lyt-1-,2+,3+ blasts displayed a significantly brighter straining than the corresponding Lyt-1+,2-,3- blasts. Isolation of the reactive molecules from T cells by immunosorption yielded a 70,000-dalton single chain polypeptide as the dominant group of molecules. Plasmin caused the chain to split into 45,000- and 25,000-dalton polypeptides, with the smaller fragment displaying antigen-binding capacity. Molecules identical in size and plasma degradation patterns were isolated from Lyt-1+,2-3- and 1-,2+,3+ blasts. Preliminary functional data supported the view that the antiserum is directed against the constant region Ctau relevant receptor structures on immunocompetent T lymphocytes.

References

Apr 1, 1979·The Journal of Experimental Medicine·H BinzH Wigzell
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Citations

Jan 1, 1983·Cancer Immunology, Immunotherapy : CII·G Parmiani, M A Pierotti
Jan 1, 1982·Immunogenetics·M SuzanB Rubin
Oct 1, 1984·Cellular Immunology·A Mackel-VandersteenhovenJ J Marchalonis
Jan 1, 1983·Molecular Aspects of Medicine·N R FaridJ C Bear
Apr 29, 1998·Immunology and Cell Biology·A al-Fahim, G W Hoffmann
Aug 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·J J MarchalonisA C Wang
Mar 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·W PtakR K Gershon
Mar 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·G M IversonR K Gershon
Apr 1, 1982·The Journal of Experimental Medicine·A J InfanteC G Fathman
Mar 1, 1983·The Journal of Experimental Medicine·P W AskenaseW Ptak
May 1, 1986·The Journal of Clinical Investigation·A DurandyC Griscelli
Jan 1, 1982·Annals of the New York Academy of Sciences·H Binz Wigzell
May 1, 1983·Immunology Today·J F MillerI D Walker

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