PMID: 2110380Apr 1, 1990Paper

T-cell recognition of HLA class II molecules induced by gamma-interferon on a colonic adenocarcinoma cell line (HT29)

Scandinavian Journal of Immunology
K E LundinE Thorsby

Abstract

HLA class II molecules may be induced on non-lymphoid cells by gamma-interferon (IFN-gamma). We investigated if HLA class II molecules induced by IFN-gamma on the HT29 colonic carcinoma cell line are functional, i.e. if they may be recognized by allogeneic T cells. We found that IFN-gamma-treated HT29 (HT29IFN) cells could not induce primary proliferative responses of peripheral blood T lymphocytes, nor were they able to induce proliferation in T-lymphocyte clones (TLC) specific for HLA class II molecules found on HT29IFN. However, in the presence of exogenous interleukin 2 (IL-2), 1 of 5 DQw8-specific TLC proliferated when restimulated with HT29IFN, and 3 of these 5 TLC could very effectively inhibit the growth of HT29IFN, probably due to a cytotoxic effect. Both the proliferative response and the cytotoxicity were inhibited by anti-DQ MoAb. We conclude that T cells may recognize HLA-DQ molecules on non-lymphoid cells, which may be of relevance for autoimmune diseases, graft-versus-host disease, and possibly for the recognition of malignant cells.

References

Mar 1, 1977·Cellular Immunology·P Matzinger, M J Bevan
Feb 1, 1987·Scandinavian Journal of Immunology·L M SollidE Thorsby
Apr 1, 1989·Journal of Immunogenetics·G Gaudernack, K E Lundin
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Citations

Jan 1, 1997·Springer Seminars in Immunopathology·P BrandtzaegJ Rugtveit
Oct 16, 1999·Scandinavian Journal of Immunology·V A OxeliusK Musil
Jun 27, 2012·Functional & Integrative Genomics·C OsorioS Rustgi
May 23, 2009·International Journal of Cancer. Journal International Du Cancer·Michael D WalshGraeme A Macdonald
Apr 1, 1997·The Tohoku Journal of Experimental Medicine·T SuzukiO Masamune
Aug 1, 1995·Scandinavian Journal of Immunology·G Boll, J Reimann
Feb 23, 2019·The Cochrane Database of Systematic Reviews·Shuxiong ZengChuanliang Xu

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