T cell recognition of xeno-MHC peptides during concordant xenograft rejection

Transplantation
B MurphyM H Sayegh

Abstract

T cell recognition of xenoantigens is likely to play a key role in rejection of xenografts surviving hyperacute and delayed xenograft rejection, but the mechanisms of how this might occur are unknown. We used synthetic rat class II MHC peptides to study the role of the indirect pathway, where processed xenogeneic MHC antigens are presented in the context of self MHC, in a concordant xenograft rejection model in vivo. Mice of four different strains, BALB/c, B1O.A, CBA/ca, and C57BL/6j, were immunized with a mixture of rat class II MHC 25-mer xenopeptides representing the full-length sequence of the beta chain hypervariable domain of either RT1.Du (DR and I-E like) or RT1.Bu (DQ and I-A like) of the Wistar-Furth (WF) (RT1u) rat. Draining lymph node cells were capable of recognizing and proliferating to specific class II xeno-MHC peptides. The immunogenicity of the different peptides varied with the responder mouse strain. Responder T cells were CD4+, and were inhibited by anti-I-A and anti-I-E antibodies. We then examined the proliferative response of T cells from B1O.A primed by WF skin or vascularized cardiac xenografts to the class II MHC xenopeptides, when presented by naive B1O.A splenic antigen-presenting cells. These T cel...Continue Reading

References

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Citations

Jul 18, 2003·Current Diabetes Reports·Gina R Rayat, Ronald G Gill
Sep 29, 1999·Transplantation Proceedings·O MillánJ Martorell
Jun 6, 2000·Advanced Drug Delivery Reviews·A G MikosJ E Babensee
Jul 17, 1999·Human Immunology·S BrouardJ P Soulillou
Apr 1, 1998·Transplantation·S ShishidoT Mohanakumar
Nov 11, 2005·American Journal of Therapeutics·Weiping Zang, Barbara Murphy
Jan 1, 1995·Annual Review of Medicine·D J Steele, H Auchincloss
Jul 14, 2012·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Robert J PlenterBiagio A Pietra
Apr 30, 2005·Immunology Letters·Guido SireciAlfredo Salerno
Apr 9, 1998·The Surgical Clinics of North America·J F Valente, J W Alexander
Dec 17, 2005·Cell Transplantation·Caroline MartinPhilippe Brachet
Oct 14, 2005·Journal of the American Society of Nephrology : JASN·Weiping ZangBarbara Murphy
Apr 26, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·Y LinF H Bach
Nov 27, 2002·Transplantation·Deng-Ping YinAnita S Chong
Sep 30, 2003·Journal of the American Society of Nephrology : JASN·Inmaculada Díaz VarelaFrancisco Valdés Cañedo
Mar 28, 2003·Journal of the American Society of Nephrology : JASN·Barbara MurphyMohamed H Sayegh

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