T-cell regulation in chronic paranasal sinus disease

The Journal of Allergy and Clinical Immunology
Nicholas Van BruaenePhilippe Gevaert

Abstract

Chronic rhinosinusitis is an inflammatory disease with distinct cytokine and remodeling patterns. Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by a T(H)2-skewed eosinophilic inflammation, whereas chronic rhinosinusitis without nasal polyps (CRSsNP) represents a predominant T(H)1 milieu. We aimed to study the direct tissue expression of transcription factors for T-cell subpopulations, including T regulatory cells, in relation to the cytokine expression patterns in the different disease subgroups. The expression of forkhead box P3 (FOXP3), T-box transcription factor (T-bet), GATA-3, retinoid acid-related orphan receptor C (RORc), the suppressive cytokines TGF-beta1 and IL-10, and T(H)1/ T(H)2/ T(H)17 cytokines (IFN-gamma, IL-4, IL-5, IL-13, IL-17) were analyzed by means of RT-PCR in 13 CRSsNP, 16 CRSwNP, and 10 control samples. Additional protein measurements were performed for TGF-beta1 and IFN-gamma. In CRSwNP, we observed a significantly lower FOXP3 mRNA and TGF-beta1 protein expression, but a significantly higher T-bet, GATA-3, IL-5, and IL-13 mRNA expression compared with controls, whereas RORc was not significantly different compared with controls. In CRSsNP, FOXP3, T-bet, GATA-3, and RORc expression w...Continue Reading

References

Oct 1, 1995·The Journal of Allergy and Clinical Immunology·D L HamilosQ Hamid
Jul 1, 1996·The Journal of Experimental Medicine·H GrouxM G Roncarolo
Jun 1, 1997·The Journal of Allergy and Clinical Immunology·C BachertC Rudack
Feb 9, 1999·The Journal of Allergy and Clinical Immunology·Y NakamuraQ Hamid
Nov 9, 2000·American Journal of Rhinology·C BachertP van Cauwenberge
Jan 11, 2003·Science·Shohei HoriShimon Sakaguchi
Mar 4, 2003·Nature Immunology·Jason D FontenotAlexander Y Rudensky
Mar 24, 2004·Seminars in Immunology·Kingston H G Mills, Peter McGuirk
Dec 4, 2004·The Journal of Allergy and Clinical Immunology·Christian KaragiannidisCarsten B Schmidt-Weber
Mar 9, 2005·Proceedings of the National Academy of Sciences of the United States of America·Mindi R WalkerJane H Buckner
Oct 18, 2005·Nature Immunology·Jason D FontenotAlexander Y Rudensky
Nov 9, 2005·The Journal of Allergy and Clinical Immunology·Mübeccel AkdisCezmi A Akdis
Jan 3, 2006·The Journal of Allergy and Clinical Immunology·Johan VerhagenCezmi A Akdis
Aug 15, 2006·Immunological Reviews·Dale T Umetsu, Rosemarie H DeKruyff
Apr 12, 2007·American Journal of Rhinology·Claudia R FigueiredoLuc L M Weckx
May 17, 2007·Expert Opinion on Therapeutic Targets·Zhaofeng HuangZuoming Sun
Aug 2, 2007·The Journal of Allergy and Clinical Immunology·Carsten B Schmidt-WeberCezmi A Akdis
Sep 18, 2007·Chest·Mark Larché
Oct 13, 2007·The Journal of Allergy and Clinical Immunology·Troy R Torgerson, Hans D Ochs

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Citations

Dec 6, 2011·HNO·B A StuckUNKNOWN German Society of Otorhinolaryngology, Head and Neck Surgery
Apr 8, 2009·Current Allergy and Asthma Reports·Andrew P Lane
Dec 12, 2012·Current Allergy and Asthma Reports·Chunwei LiDe-Yun Wang
Mar 3, 2011·Current Infectious Disease Reports·Stella Lee, Andrew P Lane
Oct 17, 2012·Cornea·Shigeo Koyasu
Dec 8, 2009·Current Opinion in Otolaryngology & Head and Neck Surgery·Bruce K TanRobert C Kern
Feb 26, 2010·Current Opinion in Otolaryngology & Head and Neck Surgery·Matthew W Ryan, Laurie S Davis
Dec 18, 2012·Current Opinion in Otolaryngology & Head and Neck Surgery·Harsha H Kariyawasam, Giuseppina Rotiroti
Mar 20, 2013·BioMed Research International·Takashi KojimaNorimasa Sawada
Oct 19, 2012·International Archives of Allergy and Immunology·Mitsuhiro OkanoKazunori Nishizaki
Nov 11, 2011·American Journal of Respiratory and Critical Care Medicine·Xin-Hao ZhangZheng Liu
Sep 13, 2008·American Journal of Rhinology·Robert C KernRobert P Schleimer
Jan 11, 2014·Current Allergy and Asthma Reports·Xin-Hao ZhangZheng Liu
May 16, 2013·Cellular and Molecular Life Sciences : CMLS·Koen Van CrombruggenClaus Bachert
Apr 29, 2010·Current Allergy and Asthma Reports·C BachertN Zhang
Apr 8, 2009·Current Allergy and Asthma Reports·Wouter HuvenneClaus Bachert
Dec 18, 2015·Current Allergy and Asthma Reports·Kathryn E Hulse
Dec 29, 2015·Current Allergy and Asthma Reports·Kathrin Scheckenbach, Martin Wagenmann
Mar 12, 2016·Seminars in Immunopathology·Leonie van RijtRonald van Ree
Mar 6, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G XuH B Li
Nov 26, 2015·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Shintaro BabaTatsuya Yamasoba
Jun 13, 2015·American Journal of Respiratory and Critical Care Medicine·Whitney W StevensRobert P Schleimer
Feb 13, 2015·DNA and Cell Biology·Jaroslaw MilonskiJurek Olszewski
Mar 10, 2015·Allergy, Asthma & Immunology Research·Yu ZhangClaus Bachert
Jan 3, 2012·Allergy, Asthma & Immunology Research·Kannika RoongrotwattanasiriToshiaki Yagi
Oct 4, 2011·Allergy, Asthma & Immunology Research·Harsha H Kariyawasam, Glenis K Scadding
May 13, 2009·Clinical and Experimental Otorhinolaryngology·De Yun Wang
Dec 6, 2014·Current Opinion in Allergy and Clinical Immunology·Claudina A Pérez-Novo, Claus Bachert
Apr 30, 2016·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Katrin KönigMoritz Gröger
Jun 9, 2009·The Journal of Allergy and Clinical Immunology·Nicholas Van BruaeneClaus Bachert
Nov 3, 2009·Immunology and Allergy Clinics of North America·Wytske J FokkensCornelis M van Drunen
Nov 7, 2012·Current Opinion in Allergy and Clinical Immunology·Harumi SuzakiRuby Pawankar
Aug 9, 2011·Current Opinion in Allergy and Clinical Immunology·Heidi Olze, Torsten Zuberbier
Sep 19, 2016·The Journal of Allergy and Clinical Immunology·Bruce K TanAtsushi Kato
Aug 22, 2016·The Journal of Allergy and Clinical Immunology·Xiangdong WangClaus Bachert
Feb 24, 2015·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Tomohisa IinumaToshinori Nakayama
Mar 26, 2016·International Forum of Allergy & Rhinology·Dijana MiljkovicSarah Vreugde

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