PMID: 6969777Jan 1, 1981Paper

T cell regulation of IgG subclass antibody production in response to T-independent antigens

The Journal of Experimental Medicine
P K MonginiW E Paul

Abstract

The effect of T lymphocytes on the IgM, IgG3, IgG1, IgG2b, and IgG2a responses of B lymphocytes to the type-2 T-independent antigens, trinitrophenylated (TNP)-Ficoll, and TNP-Levan, was investigated. T cell-bearing nu/+ mice were found to produce substantially higher IgG2 serum anti-TNP antibody than their athymic counterparts, and nu/nu and nu/+ IgG2a titers exhibiting more disparity than nu/nu and nu/+ IgG2b titers. The Igm, IgG3, and IgG1 anti-TNP levels in nu/nu and nu/+ mice were indistinguishable. By cell transfer experiments, it was determined that this variance in nude and heterozygote IgG2 responses could not be explained by B cell differences between the two strains or by suppressive effects on IgG2 production within nu/nu mice. Rather, the difference was shown to be the result of the absence of T cells at the time B cells were responding to antigen. In the absence of T cells, the strength of the nu/nu anti-TNP antibody response was found to be in the following order: IgM > IgG3 > IgG1 > IgG2b > IgG2a, a heirarchy identical with the recently proposed heavy chain gene order. The possibilities that T cells influence IgG2 production via their specific recognition of IgG2-bearing B cells or via signals to increase heavy c...Continue Reading

References

Oct 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·C A JanewayH Wigzell
May 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·T Honjo, T Kataoka
Mar 1, 1979·The Journal of Experimental Medicine·C O ElsonW Strober
Jan 1, 1977·Immunological Reviews·D E MosierW E Paul
Apr 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·R MakiS Tonegawa
Jul 1, 1965·The Journal of Experimental Medicine·J L FAHEY, S SELL

❮ Previous
Next ❯

Citations

Sep 5, 2012·Immunologic Research·Cristina L SwansonRaul M Torres
Apr 1, 1988·Molecular Immunology·M C SnellerW Strober
Jan 1, 1993·Immunology Today·C M Snapper, J J Mond
Apr 1, 1995·Current Opinion in Immunology·R J Armitage, M R Alderson
Jun 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·T FrancusC G Becker
Jan 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·K S HathcockR J Hodes
Nov 1, 1981·The Journal of Experimental Medicine·Y N LiuJ L Schulman
Feb 1, 1982·The Journal of Experimental Medicine·N A Speck, S K Pierce
Mar 1, 1982·The Journal of Experimental Medicine·P C IsaksonP H Krammer
Nov 1, 1983·The Journal of Experimental Medicine·F IvarsA Coutinho
Dec 1, 1984·The Journal of Experimental Medicine·J E LaytonP H Krammer
Jan 1, 1985·The Journal of Experimental Medicine·L MayerH G Kunkel
Oct 1, 1985·The Journal of Experimental Medicine·S M RudichP K Mongini
Jan 1, 1987·The Journal of Experimental Medicine·J P CoutelierJ Van Snick
Aug 1, 1987·The Journal of Experimental Medicine·K A DenisO N Witte
Nov 1, 1994·The Journal of Experimental Medicine·B R RenshawC R Maliszewski
Feb 1, 1996·The Journal of Experimental Medicine·E Szomolanyi-Tsuda, R M Welsh
Jun 23, 2010·The Journal of Experimental Medicine·Cristina L SwansonRaul M Torres
Jun 1, 1997·AIDS Patient Care and STDs·R M Rutstein, S E Starr
Nov 1, 1983·The Journal of Clinical Investigation·D LevittM D Cooper
Apr 1, 1985·The Journal of Clinical Investigation·R A EisenbergW J Yount
Jan 1, 1984·Immunological Communications·D P Sarkar, M K Das
Aug 19, 2014·Journal of Pharmaceutical Sciences·Merry ChristieJohn F Carpenter
Jan 11, 2013·The Journal of Investigative Dermatology·Anna L FurmanskiTessa Crompton
Sep 1, 1983·Annales d'immunologie·R Rousseaux-PrévostJ Rousseaux
Feb 1, 2012·Annals of the New York Academy of Sciences·Clifford M Snapper
Feb 1, 1983·Scandinavian Journal of Immunology·D A RivierM F Kagnoff
Jan 1, 1982·Immunological Reviews·Y J Rosenberg

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.