PMID: 6977611Mar 1, 1982Paper

T cell regulation of immunoglobulin class expression in the antibody response to trinitrophenyl-ficoll. Evidence for T cell enhancement of the immunoglobulin class switch

The Journal of Experimental Medicine
P K MonginiE S Metcalf

Abstract

In the absence of T cells, B cells were found to respond to the type 2 T-independent (TI-2) antigen, trinitrophenyl (TNP)-Ficoll, with a characteristic hierarchy of IgM and IgG subclass Ab production which directly correlated with 5' to 3' Igh-C gene order, i.e., IgM greater tha IgG3 greater than IgG1 greater than IgG2b greater than IgG2a. This was evident when immune serum Ab titers were analyzed, when in vitro secretion of antibody from immune cells was measured and when TNP-Ficoll-stimulated clones in a splenic focus assay were analyzed for isotype production. T cells were found to cause a preferential relative increase in the amount of IgG2a antibody produced to TNP-Ficoll. The T cell responsible was present in anti-IgM neonatally suppressed mice and was needed early in the response, i.e., on the day of immunization or earlier. T cells were found to increase the frequency of TNP-Ficoll-responsive B cell clones that produced IgG2a in the splenic focus assay. The great majority of these IgG2a-positive clones also produced IgM and all or nearly all of the IgG isotypes whose genes are encoded 5' to the Igh-gamma 2a gene. The data are discussed in terms to T cell enhancement of IgG2a Ab synthesis being mediated through T cell en...Continue Reading

References

Oct 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·C A JanewayH Wigzell
Jun 1, 1978·The Journal of Experimental Medicine·J AnderssonF Melchers
Mar 1, 1979·The Journal of Experimental Medicine·C O ElsonW Strober
Feb 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·P Hunter, J R Kettman
Mar 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·Y NishidaT Honjo
Sep 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·P J GearhartJ J Cebra
May 1, 1980·The Journal of Experimental Medicine·L A HerzenbergL A Herzenberg
Jan 1, 1981·The Journal of Experimental Medicine·P K MonginiW E Paul

❮ Previous
Next ❯

Citations

Sep 5, 2012·Immunologic Research·Cristina L SwansonRaul M Torres
Sep 1, 1983·Molecular Immunology·M E ConleyS D Douglas
Apr 1, 1988·Molecular Immunology·M C SnellerW Strober
Apr 11, 1995·Proceedings of the National Academy of Sciences of the United States of America·H H WortisD C Parker
Feb 1, 1983·The Journal of Experimental Medicine·R A EzekowitzS Gordon
Nov 1, 1983·The Journal of Experimental Medicine·F IvarsA Coutinho
Jan 1, 1985·The Journal of Experimental Medicine·L MayerH G Kunkel
Feb 1, 1987·The Journal of Experimental Medicine·L W Duran, E S Metcalf
Aug 1, 1987·The Journal of Experimental Medicine·K A DenisO N Witte
Nov 1, 1983·The Journal of Clinical Investigation·D LevittM D Cooper
Jan 1, 1987·International Reviews of Immunology·T J WaldschmidtR G Lynch
May 12, 2001·The Journal of Investigative Dermatology·S GazzanigaR Wainstok
Sep 1, 1983·Annales d'immunologie·R Rousseaux-PrévostJ Rousseaux
Jun 15, 2005·Scandinavian Journal of Immunology·R B CorleyA R Ferguson
Jun 1, 1989·Clinical Immunology and Immunopathology·P AucouturierP Lesavre
Apr 1, 1989·Clinical Immunology and Immunopathology·P AucouturierJ L Preud'Homme
Jun 30, 1983·Annals of the New York Academy of Sciences·M F Kagnoff
Jun 30, 1983·Annals of the New York Academy of Sciences·J J CebraR D Shahin
Jul 22, 1982·Nature·K B Marcu, M D Cooper
Mar 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C D SurhM E Gershwin
May 20, 2003·Immunology and Cell Biology·Aruna P KodituwakkuDon M Roberton
Dec 15, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Judit CervenakImre Kacskovics
Aug 1, 1985·Annals of Tropical Medicine and Parasitology·S G AndradeM B Netto

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.