PMID: 9420478Jan 1, 1997Paper

T cell repertoire: genomic or somatic bias toward recognition of major histocompatibility complex molecules?

Hereditas
D VidovićZ A Nagy

Abstract

The prevailing concept about a major influence of thymic positive selection on shaping the T cell repertoire during ontogeny is confronted with an old idea emphasizing a dominant role for genetic (evolutionary) factors in molding the recognition potential of mature T cells. Our recent results are not readily interpreted without introducing a new version of the old concept, according to which complementarity to the major histocompatibility complex peptide-binding site is a major evolutionary selective pressure on T cell antigen receptor variable genes, with alloreactivity being a reflection of this fact.

References

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Citations

Jun 3, 1999·Scandinavian Journal of Immunology·R E Langman, M Cohn

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