T cell replicative senescence: pleiotropic effects on human aging

Annals of the New York Academy of Sciences
Rita B Effros

Abstract

Long-term culture studies using CD8 T cells, the immune cells responsible for control of viral infection, have identified the major features of replicative senescence. Aging is associated with increased proportions of CD8 T cells with similar characteristics, such as absence of expression of the CD28 costimulatory molecule and reduced antiviral effector functions. Proinflammatory cytokines produced by senescent CD8 T cells also may exert pleiotropic suppressive effects on overall immune function and bone homeostasis. Thus, modulation of T cell replicative senescence may provide a comprehensive therapeutic strategy to prevent multiple age-associated pathologies.

References

Feb 17, 1998·Developmental and Comparative Immunology·R B Effros
May 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maria Saurwein-TeisslBeatrix Grubeck-Loebenstein
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Dec 17, 2002·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Hector F Valenzuela, Rita B Effros

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Citations

Feb 24, 2009·Age·D G A Burton
Apr 16, 2009·Current Infectious Disease Reports·Kelly A Gebo, Amy Justice
Jul 17, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Rita B EffrosKevin P High
Oct 27, 2010·Ageing Research Reviews·Vivian Iida Avelino-SilvaSigrid De Sousa Santos
Nov 4, 2006·Journal of Immunological Methods·S Alice LongMark Bonyhadi
Sep 7, 2016·Journal of Aging Research·Bonaventura C T Mpondo
May 2, 2015·Journal of Health and Social Behavior·Arline T GeronimusElizabeth H Blackburn
Jun 18, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Patrick A CalvertMartin R Bennett
Jan 6, 2017·Current Protocols in Cytometry·Andrea L HenningBrian K McFarlin
Jan 5, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jacek M WitkowskiAgnieszka Jóźwik

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