T cell response to grass pollen allergens: correlation with skin test reactivity and serum IgE levels

Immunology and Cell Biology
B BlaherJ M Rolland

Abstract

T cell proliferative responses to rye and Bermuda grass pollen allergens have been studied in a series of 51 atopic and 18 non-atopic subjects. Mean T cell responses were higher in the atopic group than in the non-atopic group (P < 0.001), and there was a strong correlation between the magnitude of reaction in the T cell assay and in the skin test (rye P < 0.01, Bermuda P < 0.05). A similar association was shown between T cell reactivity and serum levels of allergen-specific IgE (rye P < 0.05, Bermuda P < 0.05), but no relationship was found between serum allergen-specific IgG levels and any other parameter studied. T cell reactivity was not found in three cord blood samples tested. Discordance between positivity for T cell responses and skin test reactions in some cases might reflect reactivity by T cell subsets that promote IgG antibody or cell-mediated responses without IgE antibody production. A precise knowledge of T cell recognition of grass pollen allergens will provide exciting new prospects for more effective and safer immunotherapy strategies for allergic diseases including asthma.

References

Aug 1, 1977·Acta Allergologica·T J YooC Heath
Jan 1, 1979·The Journal of Allergy and Clinical Immunology·D R Ownby, R H Buckley
Jan 1, 1992·International Archives of Allergy and Immunology·S Romagnani
May 1, 1992·The Journal of Allergy and Clinical Immunology·R M O'BrienA M Wootton
Jan 1, 1991·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P G Holt, C McMenamin
May 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·P ParronchiS Romagnani
Nov 1, 1991·The Journal of Allergy and Clinical Immunology·F MatthiesenH Løwenstein
Sep 1, 1989·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D M KemenyM H Lessof
Jan 1, 1986·International Archives of Allergy and Applied Immunology·R HalvorsenE Thorsby
May 1, 1987·The Journal of Allergy and Clinical Immunology·S A Ford, B A Baldo
Jan 1, 1986·International Archives of Allergy and Applied Immunology·S A Ford, B A Baldo
Oct 6, 1973·British Medical Journal·K N McNichol, H E Williams
Jan 1, 1982·Archives of Dermatology·W L EllistonC C Huntley
Nov 1, 1980·The Journal of Allergy and Clinical Immunology·P L Black, D G Marsh

❮ Previous
Next ❯

Citations

Sep 15, 2005·Journal of Clinical Immunology·Fiona K GibbonsPatricia W Finn
Jan 23, 1999·Current Opinion in Immunology·J Rolland, R O'Hehir
Jul 11, 2006·Veterinary Dermatology·T J NuttallUNKNOWN members of the International Task Force on Canine Atopic Dermatitis
May 8, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T J NuttallP B Hill
Oct 2, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·W Smith, P D Sly
May 1, 1997·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C RusznakR J Davies

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

Related Papers

International Archives of Allergy and Immunology
R J van NeervenP Würtzen
International Archives of Allergy and Immunology
A M SmithM D Chapman
Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
Z Tempels-PavlicaR C Aalberse
Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
M van Hage-Hamsten
Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
M J VisserH F Kauffman
© 2021 Meta ULC. All rights reserved