PMID: 2496721Feb 1, 1989Paper

T-cell response towards HIV in infected individuals with and without zidovudine therapy, and in HIV-exposed sexual partners

AIDS
A RankiK Krohn

Abstract

HIV-specific T-cell response in HIV-infected individuals at different stages of the disease and during zidovudine therapy was studied using HIV and HIV-envelope derived native and recombinant proteins as antigens. Neither antibody-negative at-risk individuals nor HIV-infected individuals responded to HIV or its envelope-derived proteins, even though they responded to a recall antigen, purified protein derivative of tuberculin (PPD). However, five out of 14 antibody- and antigen-negative sexual partners of known HIV-positive men did respond to HIV, native gp 120 and recombinant envelope and core proteins. Some AIDS-related complex (ARC) and AIDS patients treated with zidovudine also showed a low T-cell response which diminished along with clinical deterioration. A synthetic peptide representing one of the major T-cell epitopes in HIV envelope, frequently recognized by immunized and infected primates, gave only marginal stimulation in man. Our findings suggest that HIV infection in man results in a T-helper cell anergy directed against viral proteins. The response observed in the antibody- and antigen-negative sexual partners and in some of the zidovudine-treated patients implies that at least some epitopes on HIV envelope are im...Continue Reading

Citations

Oct 1, 1990·Immunology Today·A Amadori, L Chieco-Bianchi
Dec 1, 1994·Immunology Today·M Clerici, G M Shearer
Apr 1, 1993·Trends in Microbiology·A R McLean
Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S AbrignaniT Staehelin
Dec 12, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Louise KuhnCaroline Tiemessen
Feb 1, 1994·AIDS Research and Human Retroviruses·F LolliB Wahren
May 1, 1996·AIDS Research and Human Retroviruses·C G RobertsA S De Groot
Jan 1, 1997·AIDS Research and Human Retroviruses·A D KelleherD A Cooper
Jul 3, 2013·AIDS Research and Human Retroviruses·Laura PattaciniJennifer M Lund
May 10, 2001·Clinical Obstetrics and Gynecology·R B Ferreiro, K A Sepkowitz
Dec 23, 2008·AIDS·Masaaki MiyazawaUNKNOWN ESN Study Group
Jul 25, 2000·Clinical Microbiology Reviews·E M BeltramiM E Chamberland
Aug 6, 2000·Clinical Chemistry and Laboratory Medicine : CCLM·J WestermannC Krüger
Feb 9, 2012·The Indian Journal of Medical Research·Gaurav SharmaNarinder Mehra
Feb 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·S A StranfordJ A Levy
Apr 7, 2009·Annals of Epidemiology·Roger Detels
Mar 1, 1991·Journal of the American Academy of Dermatology·A RankiK Krohn
Jan 17, 2014·American Journal of Reproductive Immunology : AJRI·Ruizhong Shen, Phillip D Smith
Feb 4, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mara BiasinMario Clerici
Dec 22, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dorothée MisséFrancisco Veas
May 28, 1993·Science·J SalkG M Shearer

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