PMID: 9451551Feb 6, 1998Paper

T-cell-rich B-cell lymphoma: fine-needle aspiration cytology and immunocytochemistry

Diagnostic Cytopathology
E TaniL Skoog

Abstract

Cytomorphologic and immunocytochemical characteristics of FNA aspirates from 5 patients with T-cell-rich B-cell lymphoma are described. The aspirates were dominated (over 90%) by small mature lymphocytes, but there was a sparse admixture of large, immature lymphoid cells, some of which mimicked Hodgkin's or Reed Sternberg's cells. The cytologic picture of 3 cases was similar to that of Hodgkin's disease of lymphocytic predominance. Two cases presented, in addition to the components described above, fragments of small vessels and epithelioid cells, which raised the possibility of true T-cell lymphoma. Immunocytochemical analysis of cytospin preparations showed that the mature small lymphocytes were of T-phenotype, while the large cells were of B-phenotype. Light-chain restriction was demonstrated in all cases, and monoclonality for kappa and lambda was shown in 4 cases and 1 case, respectively. Three cases had a previous histological diagnosis of Hodgkin's disease, which was revised to T-cell-rich B-cell lymphoma as a consequence of the cytologic and immunologic findings in aspirates from recurrent/remaining lymphoma manifestations. It can thus be concluded that immunocytochemistry in conjunction with cytomorphology on fine-need...Continue Reading

References

Apr 1, 1992·The American Journal of Surgical Pathology·W R MaconJ B Cousar
Sep 1, 1991·Histopathology·S M ChittalG Delsol
Apr 1, 1989·The American Journal of Surgical Pathology·A ScarpaM Chilosi
Jun 1, 1988·The American Journal of Surgical Pathology·A D RamsayP G Isaacson
Oct 1, 1985·Cancer·I MirchandaniM S Pak
Aug 1, 1980·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·H SteinJ Gerdes
Feb 1, 1996·The American Journal of Surgical Pathology·J A McBrideW C Pugh

❮ Previous
Next ❯

Citations

Apr 18, 2009·Diagnostic Cytopathology·Dilip K DasThamradeen A Junaid
Oct 28, 2003·Cancer·John P Crapanzano, Oscar Lin
Apr 8, 2011·Diagnostic Cytopathology·Dilip K DasIssam M Francis
Jul 31, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sean T HehnThomas P Miller
Jun 10, 2005·Diagnostic Cytopathology·Yasunobu FunamotoShoji Kobayashi
Oct 20, 2000·Cancer·N A Young, T Al-Saleem

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.