PMID: 9539370Apr 16, 1998Paper

T-cell-rich B-cell lymphoma in a pig

Veterinary Pathology
T Tanimoto, Y Ohtsuki

Abstract

A case of multicentric lymphoma with a mixed cell population of large to small round cells with the same nuclear features in a pig was studied immunohistochemically. Neoplastic tissues were composed of 20-50% B-cell lymphoma cells with lambda-type light chain restriction, and 50-80% cluster of differentiation (CD)3+ T-cells. These findings were similar to those of human T-cell-rich B-cell lymphoma (TCRBCL). In addition, both immunoglobulin IgM and IgG were detected in the cytoplasm of the identical lymphoma cell. This pattern of heavy chain expression appeared to be due to maturational arrest in cellular development at the point of heavy chain class switching, as occurs in biclonal gammopathy in human lymphoid malignancy. This case as TCRBCL containing two types of heavy chains with light chain restriction (IgM-lambda and IgG-lambda) appears to be the first of its kind reported in the English literature for either pigs or domestic animals.

References

Aug 1, 1979·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J L GuesdonS Avrameas
Nov 1, 1994·Veterinary Pathology·T TanimotoY Ohtsuki
Jan 1, 1997·Veterinary Pathology·K E SteeleG D Coleman

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Citations

Jul 21, 2014·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Petra MusilovaJiri Rubes
Oct 12, 2007·New Zealand Veterinary Journal·A L RaffertyR B Suepaul
Oct 18, 2003·Experimental Animals·Masaki MichishitaKimimasa Takahashi
Nov 10, 2004·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·T D VoE Gruys
Mar 15, 2005·Veterinary Ophthalmology·Riccardo StoppiniGiampiero Brigati
Sep 3, 2003·Xenotransplantation·Yigang LuoRobert Zhong
Mar 29, 2003·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Mamoru KameyamaKoichi Kadota
Feb 7, 2012·Veterinary Pathology·J M RitterM Kiupel
Oct 31, 2000·Veterinary Pathology·S M AquinoE J Ehrhart
Jul 6, 2014·Journal of Feline Medicine and Surgery·Jamie A NewtonJenny Helm
Oct 7, 2014·The Journal of Veterinary Medical Science·Tae-Ho ChungUl-Soo Choi

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