T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation.

Nature Immunology
Sarah E HenricksonUlrich H von Andrian

Abstract

After homing to lymph nodes, CD8+ T cells are primed by dendritic cells (DCs) in three phases. During phase one, T cells undergo brief serial contacts with DCs for several hours, whereas phase two is characterized by stable T cell-DC interactions. We show here that the duration of phase one and T cell activation kinetics correlated inversely with the number of complexes of cognate peptide and major histocompatibility complex (pMHC) per DC and with the density of antigen-presenting DCs per lymph node. Very few pMHC complexes were necessary for the induction of full-fledged T cell activation and effector differentiation. However, neither T cell activation nor transition to phase two occurred below a threshold antigen dose determined in part by pMHC stability. Thus, phase one permits T cells to make integrated 'measurements' of antigen dose that determine subsequent T cell participation in immune responses.

References

Jan 14, 1994·Cell·K A HogquistF R Carbone
Apr 15, 1997·Proceedings of the National Academy of Sciences of the United States of America·M L DustinE R Unanue
Aug 18, 1999·Proceedings of the National Academy of Sciences of the United States of America·W ReesJ Kappler
Feb 24, 2000·The Journal of Experimental Medicine·A de Baey, A Lanzavecchia
May 23, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·A CasrougeP Kourilsky
Oct 18, 2000·The Journal of Experimental Medicine·R M KedlP Marrack
Oct 3, 2001·The Journal of Experimental Medicine·W WeningerU H von Andrian
Dec 4, 2001·Nature Immunology·Christoph WülfingMark M Davis
Mar 6, 2002·The Journal of Experimental Medicine·Joseph N BlattmanRafi Ahmed
Jun 8, 2002·Science·Sabine StollRonald N Germain
Oct 25, 2002·Nature·Darrell J IrvineMark M Davis
May 6, 2003·Nature Immunology·Philippe Bousso, Ellen Robey
Jul 4, 2003·Nature·J Rodrigo MoraUlrich H Von Andrian
Dec 12, 2003·Nature Reviews. Immunology·Ulrich H von Andrian, Thorsten R Mempel
Jan 9, 2004·Nature·Thorsten R MempelUlrich H Von Andrian
Mar 30, 2004·Nature Immunology·Marco A PurbhooMark M Davis
Jul 6, 2004·Immunological Reviews·William R HeathJose A Villadangos
Jul 13, 2004·Current Opinion in Immunology·Thorsten R MempelUlrich H von Andrian
Oct 7, 2004·The Journal of Experimental Medicine·Mark J MillerMichael D Cahalan
Nov 2, 2004·Nature Immunology·Stéphanie HuguesSebastian Amigorena
Nov 16, 2004·Nature Immunology·Randall L LindquistMichel C Nussenzweig
Mar 18, 2005·Annual Review of Immunology·Rebecca J GreenwaldArlene H Sharpe
Mar 18, 2005·Annual Review of Immunology·E Sergio Trombetta, Ira Mellman
Oct 12, 2005·The Journal of Experimental Medicine·Gabriele CampiMichael L Dustin
Feb 24, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xiaoyun ZhuHing C Wong
Jul 25, 2006·Immunity·Jodie S HaringJohn T Harty
Aug 26, 2006·Science·Helga SchneiderChristopher E Rudd
Dec 28, 2006·Proceedings of the National Academy of Sciences of the United States of America·Julia J UnternaehrerIra Mellman
Jan 5, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ling-Min LuMartin R Stämpfli
Feb 13, 2007·Annual Review of Immunology·Mark M DavisQi-jing Li
Feb 14, 2007·European Journal of Immunology·Jonathan M BoulterAwen M Gallimore
Feb 28, 2007·The Journal of Experimental Medicine·Tim WorbsReinhold Förster
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Zacarias GarciaPhilippe Bousso

❮ Previous
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Citations

Sep 21, 2013·Diabetologia·Joachim StørlingFlemming Pociot
Apr 27, 2012·Seminars in Immunopathology·Shuo-Wang QiaoLudvig M Sollid
Oct 16, 2008·Histochemistry and Cell Biology·Cindy NitschkeMatthias Gunzer
Jul 31, 2008·Clinical & Experimental Metastasis·Thorsten R Mempel, Christian A Bauer
Oct 5, 2011·Journal of Mammary Gland Biology and Neoplasia·Mini Bharathan, Isis K Mullarky
Feb 10, 2009·Immunologic Research·Jason M Weaver, Andrea J Sant
Sep 8, 2012·Immunologic Research·Jordan JacobelliRachel S Friedman
Mar 26, 2008·Immunology and Cell Biology·Dawn M Jelley-GibbsSusan L Swain
Apr 24, 2008·Immunology and Cell Biology·Lois L Cavanagh, Wolfgang Weninger
Mar 3, 2010·Immunology and Cell Biology·Matthew E WikstromPhilip A Stumbles
Feb 3, 2009·Nature·Dietmar ZehnMichael J Bevan
Mar 3, 2009·Nature Immunology·Nicolas FazilleauMichael G McHeyzer-Williams
Dec 18, 2009·Nature Immunology·Daniel L Mueller
Aug 20, 2008·Nature Immunology·Peter Friedl, Bettina Weigelin
Feb 21, 2008·Nature Immunology·Andrey S Shaw
Aug 22, 2009·Nature Protocols·Frederick KlauschenMartin Meier-Schellersheim
Oct 1, 2008·Nature Reviews. Immunology·Tobias JuntBurkhard Ludewig
Aug 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Brian P O'ConnorJenny P-Y Ting
May 9, 2009·Proceedings of the National Academy of Sciences of the United States of America·Jason M WeaverAndrea J Sant
Apr 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Nadine van MontfoortFerry Ossendorp
Mar 17, 2010·Proceedings of the National Academy of Sciences of the United States of America·Kristin HochwellerNatalio Garbi
Feb 5, 2011·Proceedings of the National Academy of Sciences of the United States of America·Juan QuielWilliam E Paul
May 18, 2011·Proceedings of the National Academy of Sciences of the United States of America·Boryana N ManzJay Groves
Dec 14, 2011·Proceedings of the National Academy of Sciences of the United States of America·Qing HanJ Christopher Love
Jan 10, 2012·Proceedings of the National Academy of Sciences of the United States of America·Rachel A GottschalkJames P Allison
Dec 26, 2013·The Journal of Cell Biology·Michael J OphirStephen C Bunnell
Apr 8, 2009·The Journal of Experimental Medicine·Roberto A MaldonadoLaurie H Glimcher
Jul 28, 2010·The Journal of Experimental Medicine·Rachel A GottschalkJames P Allison
Nov 10, 2010·The Journal of Experimental Medicine·Julian PulecioFederica Benvenuti
Nov 2, 2011·The Journal of Experimental Medicine·Heather D HickmanJonathan W Yewdell
Sep 21, 2013·Lymphatic Research and Biology·Matthew C WoodruffMichael C Carroll
May 28, 2010·International Immunology·Joshua J Obar, Leo Lefrançois
May 26, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Guang-Bi JinB Paige Lawrence
Sep 17, 2010·Cold Spring Harbor Perspectives in Biology·Michael L DustinAndrey S Shaw
Jun 3, 2010·Cold Spring Harbor Perspectives in Biology·Jesse CowardGrégoire Altan-Bonnet
Jun 30, 2012·Science·Ronald N GermainMichael D Cahalan
Apr 23, 2008·Molecular and Cellular Biology·Huan ZhengArup K Chakraborty
Dec 9, 2009·Annual Review of Immunology·David R FooksmanMichael L Dustin
Jan 12, 2011·Annual Review of Immunology·Ronald N GermainIain D C Fraser
Dec 3, 2011·The Journal of Clinical Investigation·Ken CoppietersMatthias von Herrath

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