T-Cell-Specific Deletion of Map3k1 Reveals the Critical Role for Mekk1 and Jnks in Cdkn1b-Dependent Proliferative Expansion

Cell Reports
Tesha SuddasonEwen Gallagher

Abstract

MAPK signaling is important for T lymphocyte development, homeostasis, and effector responses. To better understand the role of Mekk1 (encoded by Map3k1) in T cells, we conditionally deleted Map3k1 in Lck(Cre/+)Map3k1(f/f) mice, and these display larger iNKT cell populations within the liver, spleen, and bone marrow. Mekk1 signaling controls splenic and liver iNKT cell expansion in response to glycolipid antigen. Lck(Cre/+)Map3k1(f/f) mice have enhanced liver damage in response to glycolipid antigen. Mekk1 regulates Jnk activation in iNKT cells and binds and transfers Lys63-linked poly-ubiquitin onto Carma1. Map3k1 is critical for the regulation of p27(Kip1) (encoded by Cdkn1b).

References

Jan 1, 1990·Annual Review of Immunology·H von Boehmer
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·A GosslerR Kemler
May 12, 1995·Science·A BendelacR R Brutkiewicz
Jul 9, 1996·Proceedings of the National Academy of Sciences of the United States of America·K MakiK Ikuta
Oct 23, 1998·The Journal of Experimental Medicine·F M SpadaS A Porcelli
Feb 24, 2001·Experimental Physiology·B Ledermann
Sep 3, 2005·The Journal of Clinical Investigation·Vrajesh V ParekhLuc Van Kaer
Feb 1, 2006·Proceedings of the National Academy of Sciences of the United States of America·Ewen GallagherMichael Karin
Mar 25, 2006·The Journal of Clinical Investigation·K VenuprasadYun-Cai Liu
Jun 9, 2006·European Journal of Immunology·Tord LabudaNiels Odum
Dec 8, 2006·Annual Review of Immunology·Albert BendelacLuc Teyton
Jan 24, 2007·Nature Immunology·Mercedes Rincón, Roger J Davis
Mar 29, 2007·Proceedings of the National Academy of Sciences of the United States of America·Mitchell Kronenberg, Laurent Gapin
May 15, 2007·Oncogene·M RamanM H Cobb
Feb 9, 2010·Nature Immunology·Dale I GodfreyAlan G Baxter
Sep 29, 2012·Trends in Immunology·Luc Van KaerLan Wu
Sep 28, 2014·The EMBO Journal·Nikolaos CharlaftisEwen Gallagher

❮ Previous
Next ❯

Citations

Jun 2, 2016·Cell Cycle·Tesha Suddason, Ewen Gallagher
Jul 29, 2016·Microbiology and Molecular Biology Reviews : MMBR·András ZekeMarie A Bogoyevitch
Apr 1, 2016·Future Oncology·Gustav van NiekerkAnna-Mart Engelbrecht
Jul 16, 2016·Biological Chemistry·Isabel Meininger, Daniel Krappmann
Mar 27, 2020·Proceedings of the National Academy of Sciences of the United States of America·Sandeep KumarAjay Rana
Jun 15, 2021·Frontiers in Genetics·Marcello Del CorvoPaolo Ajmone-Marsan
May 2, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Liang SuWenbo Liang

❮ Previous
Next ❯

Methods Mentioned

BETA
protein array
PCR
ubiquitination
transgenics
biopsies
transfection
PMA
Immunoprecipitation

Software Mentioned

FlowJo
GraphPad
GraphPad Prism
Image Pro - Software
Partek
GeneSpringX
TreeStar

Related Concepts

Related Feeds

B cells: Gene Expression

B lymphocytes are white blood cells that play a role in the adaptive immune system by secreting antibodies. Here is the latest research on gene expression in B cells.

Related Papers

The Journal of Experimental Medicine
Natalie A BezmanLewis L Lanier
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme
Yasunori Mori, Yukiko Gotoh
© 2022 Meta ULC. All rights reserved