T cell-specific overexpression of TGFß1 fails to influence atherosclerosis in ApoE-deficient mice

PloS One
Kurt ReifenbergMichael Torzewski

Abstract

Clinical data have indicated a negative correlation between plasma TGFß1 concentrations and the extent of atherosclerosis and have thus led to the hypothesis that the pleiotropic cytokine may have anti-atherogenic properties. T-cells are currently discussed to significantly participate in atherogenesis, but the precise role of adaptive immunity in atherogenesis remains to be elucidated. TGFß1 is known to strongly modulate the function of T-cells, however, inhibition of TGFß1 signalling in T-cells of atherosclerosis-prone knock-out mice failed to unequivocally clarify the role of the cytokine for the development of atherosclerosis. In the present study, we thus tried to specify the role of TGFß1 in atherogenesis by using the murine CD2-TGFß1 transgenic strain which represents a well characterized model of T-cell specific TGFß1 overexpression. The CD2-TGFß1 transgenic mice were crossed to ApoE knock-out mice and quantity and quality of atherosclerosis regarding number of macrophages, smooth muscle cells, CD3 positive T-cells and collagen was analyzed in CD2-TGFß1 ApoE double mutants as well as non-transgenic ApoE controls on both normal and atherogenic diet of a duration of 8, 16 or 24 weeks, respectively. In all experimental gro...Continue Reading

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Citations

May 26, 2015·Cytokine & Growth Factor Reviews·Dipak P Ramji, Thomas S Davies
Jul 1, 2016·Future Medicinal Chemistry·Joe We Moss, Dipak P Ramji
Sep 1, 2016·Molecular Therapy. Methods & Clinical Development·Hiroki TakedaRyosei Minoda

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